Regression of metastatic osteosarcoma following non-myeloablative stem cell transplantation. A case report.

Franca Fagioli, Massimo Berger, Adalberto Brach del Prever, Stefano Lioji, Massimo Aglietta, Stefano Ferrari, Piero Picci, Enrico Madon

Research output: Contribution to journalArticle

Abstract

report the evidence of regression of multiple metastases following non-myeloablative stem cell transplantation (NST) from an HLA-identical sibling in a case of relapsed fibroblastic osteosarcoma. The course of NST was well tolerated. Full donor chimerism was achieved on day +150 both for CD15+ and CD3+ cells. Complete remission was achieved on day +116. On day +210 the patient relapsed with a scapular metastasis that was unresponsive to four doses of donor lymphocyte infusion (DLIs).To our knowledge, this is the first reported case showing the achievement of complete remission following NST in an osteosarcoma patient.

Original languageEnglish
JournalHaematologica
Volume88
Issue number5
Publication statusPublished - May 2003

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Regression of metastatic osteosarcoma following non-myeloablative stem cell transplantation. A case report.'. Together they form a unique fingerprint.

  • Cite this

    Fagioli, F., Berger, M., Brach del Prever, A., Lioji, S., Aglietta, M., Ferrari, S., Picci, P., & Madon, E. (2003). Regression of metastatic osteosarcoma following non-myeloablative stem cell transplantation. A case report. Haematologica, 88(5).