Regular Wine Consumption in Chronic Heart Failure: Impact on Outcomes, Quality of Life, and Circulating Biomarkers

Franco Cosmi, Paola Di Giulio, Serge Masson, Andrea Finzi, Rosa Maria Marfisi, Deborah Cosmi, Marco Scarano, Gianni Tognoni, Aldo P. Maggioni, Maurizio Porcu, Silvana Boni, Giovanni Cutrupi, Luigi Tavazzi, Roberto Latini

Research output: Contribution to journalArticlepeer-review


Background-Moderate, regular alcohol consumption is generally associated with a lower risk of cardiovascular events but data in patients with chronic heart failure are scarce. We evaluated the relations between wine consumption, health status, circulating biomarkers, and clinical outcomes in a large Italian population of patients with chronic heart failure enrolled in a multicenter clinical trial. Methods and Results-A brief questionnaire on dietary habits was administered at baseline to 6973 patients enrolled in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) trial. The relations between wine consumption, fatal and nonfatal clinical end points, quality of life, symptoms of depression, and circulating biomarkers of cardiac function and inflammation (in subsets of patients) were evaluated with simple and multivariable-adjusted statistical models. Almost 56% of the patients reported drinking at least 1 glass of wine per day. After adjustment, clinical outcomes were not significantly different in the predefined 4 groups of wine consumption. However, patients with more frequent wine consumption had a significantly better perception of health status (Kansas City Cardiomyopathy Questionnaire score, adjusted P

Original languageEnglish
Pages (from-to)428-437
Number of pages10
JournalCirculation: Heart Failure
Issue number3
Publication statusPublished - May 4 2015


  • biological markers
  • quality of life
  • wine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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