Regularized ML reconstruction for time/dose reduction in 18F-fluoride PET/CT studies

Elisabetta De Bernardi, Patrizia Magnani, Luigi Gianolli, Maria Carla Gilardi, Valentino Bettinardi

Research output: Contribution to journalArticlepeer-review


We are proposing a regularized reconstruction strategy for the detection of bone lesions in 18F-fluoride whole body PET images obtained with 1 min/ bed using the anatomical information provided by co-registered CT images. Bones are recognized on CT images and then transposed into the PET volume framework. During PET reconstruction, two different priors are used for bone and non-bone voxels: the relative difference prior in bone and the P-Gaussian prior in non-bone. After a tuning of the priors' parameters, the reconstruction strategy has been tested on 6 18F-fluoride PET/CT studies, on a total of 67 lesions. Regularized images provided results comparable to the standard 3 min/bed images, in terms image quality, lesion activity, noise level and noise correlation. The proposed strategy therefore appears to be a useful tool to reduce the acquisition time or the injected dose in 18F-fluoride PET studies.

Original languageEnglish
Article number67
Pages (from-to)67-80
Number of pages14
JournalPhysics in Medicine and Biology
Issue number1
Publication statusPublished - Jan 7 2015


  • F-fluoride PET
  • Bone segmentation
  • Dose/acquisition time reduction
  • Regularized maximum likelihood reconstruction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)


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