Regulated exocytosis: A novel, widely expressed system

Barbara Borgonovo, Emanuele Cocucci, Gabriella Racchetti, Paola Podini, Angela Bachi, Jacopo Meldolesi

Research output: Contribution to journalArticlepeer-review


Electrophysiological studies in some secretory and non-secretory cells have identified an extensive form of calcium-induced exocytosis that is rapid (hundreds of milliseconds), insensitive to tetanus toxin and distinct from regulated secretion. We have now identified a marker of the process, desmoyokin-AHNAK, in a clonal derivative of the neuronal cell line, PC12. In resting cells, desmoyokin-AHNAK is localized within the lumen of specific vesicles, but appears on the cell surface during stimulation. Desmoyokin-AHNAK-positive vesicles exist in a variety of cells and tissues and are distinct from the endoplasmic reticulum, Golgi, trans-Golgi, endosomes and lysosomes, and from Glut4 and constitutive secretion vesicles. They seem to be involved in two models of plasmalemma enlargement: differentiation and membrane repair. We therefore propose that these vesicles should be called 'enlargosomes'.

Original languageEnglish
Pages (from-to)955-962
Number of pages8
JournalNature Cell Biology
Issue number12
Publication statusPublished - Dec 1 2002

ASJC Scopus subject areas

  • Cell Biology


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