Regulating the regulators: The post-translational code of class i HDAC1 and HDAC2

Susanna Chiocca, Chiara V. Segré

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Class I histone deacetylases (HDACs) are cellular enzymes expressed in many tissues and play crucial roles in differentiation, proliferation, and cancer. HDAC1 and HDAC2 in particular are highly homologous proteins that show redundant or specific roles in different cell types or in response to different stimuli and signaling pathways. The molecular details of this dual regulation are largely unknown. HDAC1 and HDAC2 are not only protein modifiers, but are in turn regulated by post-translational modifications (PTMs): phosphorylation, acetylation, ubiquitination, SUMOylation, nitrosylation, and carbonylation. Some of these PTMs occur and crosstalk specifically on HDAC1 or HDAC2, creating a rational "code" for a differential, context-related regulation. The global comprehension of this PTM code is central for dissecting the role of single HDAC1 and HDAC2 in physiology and pathology.

Original languageEnglish
Article number690848
JournalJournal of Biomedicine and Biotechnology
Volume2011
DOIs
Publication statusPublished - 2011

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Post Translational Protein Processing
Sumoylation
Histone Deacetylases
Ubiquitination
Acetylation
Proteins
Phosphorylation
Pathology
Enzymes
Neoplasms

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Regulating the regulators : The post-translational code of class i HDAC1 and HDAC2. / Chiocca, Susanna; Segré, Chiara V.

In: Journal of Biomedicine and Biotechnology, Vol. 2011, 690848, 2011.

Research output: Contribution to journalArticle

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