Regulation of acyl CoA: Cholesterol acyl transferase (ACAT) activity by mevalonate and cholesterol in isolated rat hepatocytes during perinatal development

G. Bruscalupi, L. Conti Devirgiliis, S. Leoni, F. Piemonte, A. Trentalance

Research output: Contribution to journalArticle

Abstract

Acyl CoA: cholesterol acyl transferase (ACAT) activity presents marked oscillations and differential sensitivity to the "in vitro" stimulation of the kinase-phosphatase modulatory system in the perinatal rat liver. The regulation of this enzyme activity by some modulators generally active in adulthood, such as cholesterol, lipoproteins and mevalonate, has been studied in hepatocytes isolated at different developmental stages. A lack of effect of mevalonate and a positive effort of lipoprotein cholesterol have been observed at the fetal and neonatal stages. A differential prevalence is suggested of one of the two modulatory mechanisms (phosphorylation-dephosphorylation system, or substrate effect) at each developmental stage.

Original languageEnglish
Pages (from-to)735-740
Number of pages6
JournalBioscience Reports
Volume6
Issue number8
DOIs
Publication statusPublished - Aug 1986

Keywords

  • acyl CoA: cholesterol acyltransferase
  • cholesterol
  • development (rat liver)
  • hepatocytes
  • lipoproteins
  • mevalonate

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Regulation of acyl CoA: Cholesterol acyl transferase (ACAT) activity by mevalonate and cholesterol in isolated rat hepatocytes during perinatal development'. Together they form a unique fingerprint.

Cite this