Regulation of angiostatic chemokines driven by IL-12 and IL-27 in human tumors

Irma Airoldi, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Chemokines have pleiotropic effects in regulating immunity, angiogenesis, and tumor growth. CXC and CC chemokine families members and their receptors are able to exert a proangiogenic or an antiangiogenic effect in experimental models and in human tumors. In this review article, we have summarized literature data and our studies concerning the angiostatic activity of chemokines. Their angiostatic activity may be a result of a direct effect on the biological functions of endothelial cells and/or an effect on tumor cells inhibiting their capability to stimulate new blood vessel formation. Moreover, chemokines have a pro- and antitumor effect within the tumor microenvironment by regulating immune cell infiltration and its antitumor activities. We have focused our interest on the role of IL-12 and IL-27 in solid and hematological tumors, and we have suggested and discussed their potential use as antiangiogenic agents in the treatment of such tumors.

Original languageEnglish
Pages (from-to)875-882
Number of pages8
JournalJournal of Leukocyte Biology
Volume90
Issue number5
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Angiogenesis
  • Antiangiogenesis
  • Multiple myeloma
  • Non small cell lung carcinoma

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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