Abstract
Chemokines have pleiotropic effects in regulating immunity, angiogenesis, and tumor growth. CXC and CC chemokine families members and their receptors are able to exert a proangiogenic or an antiangiogenic effect in experimental models and in human tumors. In this review article, we have summarized literature data and our studies concerning the angiostatic activity of chemokines. Their angiostatic activity may be a result of a direct effect on the biological functions of endothelial cells and/or an effect on tumor cells inhibiting their capability to stimulate new blood vessel formation. Moreover, chemokines have a pro- and antitumor effect within the tumor microenvironment by regulating immune cell infiltration and its antitumor activities. We have focused our interest on the role of IL-12 and IL-27 in solid and hematological tumors, and we have suggested and discussed their potential use as antiangiogenic agents in the treatment of such tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 875-882 |
| Number of pages | 8 |
| Journal | Journal of Leukocyte Biology |
| Volume | 90 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 2011 |
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Keywords
- Angiogenesis
- Antiangiogenesis
- Multiple myeloma
- Non small cell lung carcinoma
ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
Regulation of angiostatic chemokines driven by IL-12 and IL-27 in human tumors. / Airoldi, Irma; Ribatti, Domenico.
In: Journal of Leukocyte Biology, Vol. 90, No. 5, 11.2011, p. 875-882.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of angiostatic chemokines driven by IL-12 and IL-27 in human tumors
AU - Airoldi, Irma
AU - Ribatti, Domenico
PY - 2011/11
Y1 - 2011/11
N2 - Chemokines have pleiotropic effects in regulating immunity, angiogenesis, and tumor growth. CXC and CC chemokine families members and their receptors are able to exert a proangiogenic or an antiangiogenic effect in experimental models and in human tumors. In this review article, we have summarized literature data and our studies concerning the angiostatic activity of chemokines. Their angiostatic activity may be a result of a direct effect on the biological functions of endothelial cells and/or an effect on tumor cells inhibiting their capability to stimulate new blood vessel formation. Moreover, chemokines have a pro- and antitumor effect within the tumor microenvironment by regulating immune cell infiltration and its antitumor activities. We have focused our interest on the role of IL-12 and IL-27 in solid and hematological tumors, and we have suggested and discussed their potential use as antiangiogenic agents in the treatment of such tumors.
AB - Chemokines have pleiotropic effects in regulating immunity, angiogenesis, and tumor growth. CXC and CC chemokine families members and their receptors are able to exert a proangiogenic or an antiangiogenic effect in experimental models and in human tumors. In this review article, we have summarized literature data and our studies concerning the angiostatic activity of chemokines. Their angiostatic activity may be a result of a direct effect on the biological functions of endothelial cells and/or an effect on tumor cells inhibiting their capability to stimulate new blood vessel formation. Moreover, chemokines have a pro- and antitumor effect within the tumor microenvironment by regulating immune cell infiltration and its antitumor activities. We have focused our interest on the role of IL-12 and IL-27 in solid and hematological tumors, and we have suggested and discussed their potential use as antiangiogenic agents in the treatment of such tumors.
KW - Angiogenesis
KW - Antiangiogenesis
KW - Multiple myeloma
KW - Non small cell lung carcinoma
UR - http://www.scopus.com/inward/record.url?scp=80055087804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80055087804&partnerID=8YFLogxK
U2 - 10.1189/jlb.0511237
DO - 10.1189/jlb.0511237
M3 - Article
C2 - 21750124
AN - SCOPUS:80055087804
VL - 90
SP - 875
EP - 882
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 5
ER -