Abstract
Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.
Original language | English |
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Pages (from-to) | 873-880 |
Number of pages | 8 |
Journal | Journal of Molecular Medicine |
Volume | 88 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sep 2010 |
Keywords
- Apoptosis
- CD14
- Dendritic cells
- Innate immunity
- Toll-like receptors
ASJC Scopus subject areas
- Molecular Medicine
- Genetics(clinical)
- Drug Discovery