Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors

Ivan Zanoni, Francesca Granucci

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.

Original languageEnglish
Pages (from-to)873-880
Number of pages8
JournalJournal of Molecular Medicine
Volume88
Issue number9
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Apoptosis
  • CD14
  • Dendritic cells
  • Innate immunity
  • Toll-like receptors

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics(clinical)
  • Drug Discovery

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