Abstract
Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.
| Original language | English |
|---|---|
| Pages (from-to) | 873-880 |
| Number of pages | 8 |
| Journal | Journal of Molecular Medicine |
| Volume | 88 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2010 |
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Keywords
- Apoptosis
- CD14
- Dendritic cells
- Innate immunity
- Toll-like receptors
ASJC Scopus subject areas
- Molecular Medicine
- Genetics(clinical)
- Drug Discovery
Cite this
Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors. / Zanoni, Ivan; Granucci, Francesca.
In: Journal of Molecular Medicine, Vol. 88, No. 9, 09.2010, p. 873-880.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of antigen uptake, migration, and lifespan of dendritic cell by Toll-like receptors
AU - Zanoni, Ivan
AU - Granucci, Francesca
PY - 2010/9
Y1 - 2010/9
N2 - Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.
AB - Dendritic cells (DCs) sense the presence of pathogens through germline-encoded pattern recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms and endogenous stimuli. Toll-like receptors (TLRs) are the best characterized PRRs. TLR activation has a profound effect on a number of DC activities, including endocytosis, cytoskeleton rearrangement, migration, antigen processing and presentation, survival, and death. The goal of TLR-induced DC reprogramming is to promote the appropriate activation and differentiation of lymphocytes bearing clonally distributed antigen-specific receptors. In this review, we will focus on the functional consequences of TLR engagement for conventional DCs.
KW - Apoptosis
KW - CD14
KW - Dendritic cells
KW - Innate immunity
KW - Toll-like receptors
UR - http://www.scopus.com/inward/record.url?scp=77956409179&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956409179&partnerID=8YFLogxK
U2 - 10.1007/s00109-010-0638-x
DO - 10.1007/s00109-010-0638-x
M3 - Article
C2 - 20556351
AN - SCOPUS:77956409179
VL - 88
SP - 873
EP - 880
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
SN - 0946-2716
IS - 9
ER -