Regulation of autophagy in mammals and its interplay with apoptosis

Research output: Contribution to journalArticlepeer-review

Abstract

A growing number of publications show that apoptosis induction is often associated with increased autophagy indicating the existence of an interplay between these two important cellular events. The simultaneous activation of both phenomena has been detected not only in experimental settings but also in vivo under physiological and pathological conditions. Despite these studies, the reciprocal influence of the two pathways in vivo has still not been completely understood. It is clear that autophagy and apoptosis are strictly interconnected, as highlighted by the finding that the two pathways share key molecular regulators. Many novel aspects of the crosstalk between apoptosis and autophagy have recently emerged showing how complex is this relationship and how critical is for the overall fate of the cell. In this mini-review we will focus on some key experiments trying to decipher as to whether autophagy contributes to apoptosis modulation in vivo.

Original languageEnglish
Pages (from-to)1581-1588
Number of pages8
JournalCellular and Molecular Life Sciences
Volume67
Issue number10
DOIs
Publication statusPublished - May 2010

Keywords

  • Ambra1
  • ATG proteins
  • Beclin1 protein complex
  • BH3-only proteins
  • ER stress
  • Genotoxic stress
  • P53

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Medicine(all)
  • Cellular and Molecular Neuroscience
  • Pharmacology

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