Seven patients with uncomplicated essential hypertension were treated with increasing doses of prazosin until a significant reduction of blood pressure was achieved in each of them, and then the effective dose (2-5 mg, t.i.d) was maintained for 10-15 days. The effect of prazosin on circulation regulation was studied by comparing hemodynamics at rest, during dynamic and isometric exercise, during cold exposure, and during transient stimulation and inactivation of the carotid sinus baroreflex. Prazosin reduced both mean arterial pressure and peripheral resistance at rest without affecting heart rate and cardiac output. Neurally mediated changes in arterial pressure, cardiac output, and peripheral resistance during the various stimuli employed and during manipulation of the baroreflex were unaffected by the drug, although all blood pressure and peripheral resistance values reached during the various tests were significantly lower during than before treatment because of the lowering of resting values by prazosin. These data indicate that clinically effective doses of prazosin reduce arterial pressure without affecting circulatory homeostasis.
|Journal||Journal of Cardiovascular Pharmacology|
|Publication status||Published - 1980|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine