Regulation of endogenous E2F1 stability by the retinoblastoma family proteins

Fabio Martelli, David M. Livingston

Research output: Contribution to journalArticlepeer-review

Abstract

Certain E2F transcription factor species play a pivotal role in regulating cell-cycle progression. The activity of E2F1, a protein with neoplastic transforming activity when unregulated, is tightly controlled at the transcriptional level during G0 exit. In addition, during this interval, the stability of endogenous E2F1 protein increased markedly. E2F1 stability also was dynamically regulated during myogenic differentiation and in response to gamma irradiation. One or more retinoblastoma family proteins likely participate in the stability process, because simian virus 40 T antigen disrupted E2F1 stability regulation during G1 exit in a manner dependent on its ability to bind to pocket proteins. Thus, endogenous E2F1 function is regulated by both transcriptional and posttranscriptional control mechanisms.

Original languageEnglish
Pages (from-to)2858-2863
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number6
DOIs
Publication statusPublished - Mar 16 1999

ASJC Scopus subject areas

  • General
  • Genetics

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