Regulation of endothelial cell shape and barrier function by chromogranin A

E. Ferrero, E. Magni, F. Curnis, A. Villa, M. E. Ferrero, A. Corti

Research output: Contribution to journalArticlepeer-review

Abstract

We have found that chromogranin A (CgA), a protein released in circulation by neuroendocrine cells and neurons, prevents the vascular leakage induced by tumor necrosis factor (TNF) in a mouse model. Studies of the mechanism of action showed that CgA and its NH2-terminal fragments inhibit TNF-induced vascular permeability by preventing endothelial cytoskeleton rearrangements. We propose that neuronal/endocrine secretion of CgA could contribute to the regulation of endothelial barrier function and the protection of vessels against plasma leakage in inflammatory diseases.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume971
Publication statusPublished - Jun 5 2002

Keywords

  • Chromogranin A
  • Endothelial barrier function
  • Endothelial cells
  • Inflammatory disease
  • Tumor necrosis factor
  • Vascular leakage

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Regulation of endothelial cell shape and barrier function by chromogranin A'. Together they form a unique fingerprint.

Cite this