Regulation of endothelial cell shape and barrier function by chromogranin A

E. Ferrero; E. Magni; F. Curnis; A. Villa; M. E. Ferrero; A. Corti

Regulation of endothelial cell shape and barrier function by chromogranin A

E. Ferrero, E. Magni, F. Curnis, A. Villa, M. E. Ferrero, A. Corti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We have found that chromogranin A (CgA), a protein released in circulation by neuroendocrine cells and neurons, prevents the vascular leakage induced by tumor necrosis factor (TNF) in a mouse model. Studies of the mechanism of action showed that CgA and its NH₂-terminal fragments inhibit TNF-induced vascular permeability by preventing endothelial cytoskeleton rearrangements. We propose that neuronal/endocrine secretion of CgA could contribute to the regulation of endothelial barrier function and the protection of vessels against plasma leakage in inflammatory diseases.

Original language	English
Pages (from-to)	355-358
Number of pages	4
Journal	Annals of the New York Academy of Sciences
Volume	971
Publication status	Published - Jun 5 2002

Keywords

Chromogranin A
Endothelial barrier function
Endothelial cells
Inflammatory disease
Tumor necrosis factor
Vascular leakage

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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T1 - Regulation of endothelial cell shape and barrier function by chromogranin A

AU - Ferrero, E.

AU - Magni, E.

AU - Curnis, F.

AU - Villa, A.

AU - Ferrero, M. E.

AU - Corti, A.

PY - 2002/6/5

Y1 - 2002/6/5

N2 - We have found that chromogranin A (CgA), a protein released in circulation by neuroendocrine cells and neurons, prevents the vascular leakage induced by tumor necrosis factor (TNF) in a mouse model. Studies of the mechanism of action showed that CgA and its NH2-terminal fragments inhibit TNF-induced vascular permeability by preventing endothelial cytoskeleton rearrangements. We propose that neuronal/endocrine secretion of CgA could contribute to the regulation of endothelial barrier function and the protection of vessels against plasma leakage in inflammatory diseases.

AB - We have found that chromogranin A (CgA), a protein released in circulation by neuroendocrine cells and neurons, prevents the vascular leakage induced by tumor necrosis factor (TNF) in a mouse model. Studies of the mechanism of action showed that CgA and its NH2-terminal fragments inhibit TNF-induced vascular permeability by preventing endothelial cytoskeleton rearrangements. We propose that neuronal/endocrine secretion of CgA could contribute to the regulation of endothelial barrier function and the protection of vessels against plasma leakage in inflammatory diseases.

KW - Chromogranin A

KW - Endothelial barrier function

KW - Endothelial cells

KW - Inflammatory disease

KW - Tumor necrosis factor

KW - Vascular leakage

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AN - SCOPUS:0037024569

VL - 971

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -

Regulation of endothelial cell shape and barrier function by chromogranin A

Abstract

Keywords

ASJC Scopus subject areas

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