Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer

Research output: Contribution to journalReview article

Abstract

The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two multifunctional enzymes playing an important role in the biological processes requiring trimming of substrates, including the generation of major histocompatibility complex (MHC) class I binding peptides. In the absence of ERAP enzymes, the cells exhibit a different pool of peptides on their surface which can promote both NK and CD8+ T cell-mediated immune responses. The expression of ERAP1 and ERAP2 is frequently altered in tumors, as compared to their normal counterparts, but how this affects tumor growth and anti-tumor immune responses has been little investigated. This review will provide an overview of current knowledge on transcriptional and post-transcriptional regulations of ERAP enzymes, and will discuss the contribution of recent studies to our understanding of ERAP1 and ERAP2 role in cancer immunity.

Original languageEnglish
JournalHuman Immunology
DOIs
Publication statusE-pub ahead of print - Feb 27 2019

Fingerprint

Genes
Neoplasms
Multifunctional Enzymes
Biological Phenomena
Peptides
Aminopeptidases
Enzymes
Major Histocompatibility Complex
Endoplasmic Reticulum
Immunity
T-Lymphocytes
Growth

Cite this

@article{af386618ca9b4025a0609b1f5348ab6e,
title = "Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer",
abstract = "The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two multifunctional enzymes playing an important role in the biological processes requiring trimming of substrates, including the generation of major histocompatibility complex (MHC) class I binding peptides. In the absence of ERAP enzymes, the cells exhibit a different pool of peptides on their surface which can promote both NK and CD8+ T cell-mediated immune responses. The expression of ERAP1 and ERAP2 is frequently altered in tumors, as compared to their normal counterparts, but how this affects tumor growth and anti-tumor immune responses has been little investigated. This review will provide an overview of current knowledge on transcriptional and post-transcriptional regulations of ERAP enzymes, and will discuss the contribution of recent studies to our understanding of ERAP1 and ERAP2 role in cancer immunity.",
author = "Mirco Compagnone and Loredana Cifaldi and Doriana Fruci",
note = "Copyright {\circledC} 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = "2",
day = "27",
doi = "10.1016/j.humimm.2019.02.014",
language = "English",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer

AU - Compagnone, Mirco

AU - Cifaldi, Loredana

AU - Fruci, Doriana

N1 - Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

PY - 2019/2/27

Y1 - 2019/2/27

N2 - The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two multifunctional enzymes playing an important role in the biological processes requiring trimming of substrates, including the generation of major histocompatibility complex (MHC) class I binding peptides. In the absence of ERAP enzymes, the cells exhibit a different pool of peptides on their surface which can promote both NK and CD8+ T cell-mediated immune responses. The expression of ERAP1 and ERAP2 is frequently altered in tumors, as compared to their normal counterparts, but how this affects tumor growth and anti-tumor immune responses has been little investigated. This review will provide an overview of current knowledge on transcriptional and post-transcriptional regulations of ERAP enzymes, and will discuss the contribution of recent studies to our understanding of ERAP1 and ERAP2 role in cancer immunity.

AB - The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two multifunctional enzymes playing an important role in the biological processes requiring trimming of substrates, including the generation of major histocompatibility complex (MHC) class I binding peptides. In the absence of ERAP enzymes, the cells exhibit a different pool of peptides on their surface which can promote both NK and CD8+ T cell-mediated immune responses. The expression of ERAP1 and ERAP2 is frequently altered in tumors, as compared to their normal counterparts, but how this affects tumor growth and anti-tumor immune responses has been little investigated. This review will provide an overview of current knowledge on transcriptional and post-transcriptional regulations of ERAP enzymes, and will discuss the contribution of recent studies to our understanding of ERAP1 and ERAP2 role in cancer immunity.

U2 - 10.1016/j.humimm.2019.02.014

DO - 10.1016/j.humimm.2019.02.014

M3 - Review article

C2 - 30825518

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

ER -