Regulation of ferritin synthesis in malignant and non-malignant lymphoid cells

Gaetano Cairo, Paolo Vezzoni, Lidia Bardella, Luisa Schiaffonati, Emilia Rappocciolo, Sonia Levi, Paolo Arosio, Aldo Bernelli-Zazzera

Research output: Contribution to journalArticle

Abstract

The different amounts of H-rich and L-rich isoferritins found in malignant and non malignant lymphoid cells are accompanied by proportional variations in the relative quantity of messenger RNAs for the H and L subunits of ferritin. The correlation between levels of messenger RNAs and proteins suggests that the amount of messenger RNA plays an important role in ferritin biosynthesis in these cells. The enhanced expression of ferritin messenger RNAs in some neoplastic cells is not caused by gross alterations in the structure of ferritin genes.

Original languageEnglish
Pages (from-to)652-657
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume139
Issue number2
DOIs
Publication statusPublished - Sep 16 1986

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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