Regulation of HIV expression by viral genes and cytokines

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The human immunodeficiency virus (HIV) is the causative agent of the acquired immunodeficiency syndrome (AIDS), a leading cause of death among young individuals. As a complex pathogenic retrovirus, HIV is characterized in vitro and in vivo by the ability to establish either a latent or productive infection of CD4+ T lymphocytes and mononuclear phagocytes (MPs). Viral latency and expression are under the control of both viral genes and several host-related factors. Among these latter, several proinflammatory and immunoregulatory cytokines profoundly affect HIV replication in T lymphocytes and MPs in vitro. Because many of these cytokines have been found to be elevated in HIV-infected individuals, it is likely that they act as regulators of viral expression in vivo. Both viral genes and cytokines regulate transcriptional and posttranscriptional steps in HIV replication. Thus, it is likely that common regulatory pathways between these two distinct classes of regulator molecules will be identified in the near future and will provide potential targets for pharmacologic intervention and treatment of HIV disease.

Original languageEnglish
Pages (from-to)328-334
Number of pages7
JournalJournal of Leukocyte Biology
Volume56
Issue number3
Publication statusPublished - 1994

Fingerprint

Viral Genes
HIV
Cytokines
Phagocytes
Virus Replication
Virus Latency
T-Lymphocytes
Virus Diseases
Retroviridae
Cause of Death
Acquired Immunodeficiency Syndrome
Infection

Keywords

  • cytokines
  • genes
  • HIV
  • latency
  • pathogenesis

ASJC Scopus subject areas

  • Cell Biology

Cite this

Regulation of HIV expression by viral genes and cytokines. / Vicenzi, E.; Poli, G.

In: Journal of Leukocyte Biology, Vol. 56, No. 3, 1994, p. 328-334.

Research output: Contribution to journalArticle

@article{76c83ae718204b09a1d516ca94298b74,
title = "Regulation of HIV expression by viral genes and cytokines",
abstract = "The human immunodeficiency virus (HIV) is the causative agent of the acquired immunodeficiency syndrome (AIDS), a leading cause of death among young individuals. As a complex pathogenic retrovirus, HIV is characterized in vitro and in vivo by the ability to establish either a latent or productive infection of CD4+ T lymphocytes and mononuclear phagocytes (MPs). Viral latency and expression are under the control of both viral genes and several host-related factors. Among these latter, several proinflammatory and immunoregulatory cytokines profoundly affect HIV replication in T lymphocytes and MPs in vitro. Because many of these cytokines have been found to be elevated in HIV-infected individuals, it is likely that they act as regulators of viral expression in vivo. Both viral genes and cytokines regulate transcriptional and posttranscriptional steps in HIV replication. Thus, it is likely that common regulatory pathways between these two distinct classes of regulator molecules will be identified in the near future and will provide potential targets for pharmacologic intervention and treatment of HIV disease.",
keywords = "cytokines, genes, HIV, latency, pathogenesis",
author = "E. Vicenzi and G. Poli",
year = "1994",
language = "English",
volume = "56",
pages = "328--334",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "FASEB",
number = "3",

}

TY - JOUR

T1 - Regulation of HIV expression by viral genes and cytokines

AU - Vicenzi, E.

AU - Poli, G.

PY - 1994

Y1 - 1994

N2 - The human immunodeficiency virus (HIV) is the causative agent of the acquired immunodeficiency syndrome (AIDS), a leading cause of death among young individuals. As a complex pathogenic retrovirus, HIV is characterized in vitro and in vivo by the ability to establish either a latent or productive infection of CD4+ T lymphocytes and mononuclear phagocytes (MPs). Viral latency and expression are under the control of both viral genes and several host-related factors. Among these latter, several proinflammatory and immunoregulatory cytokines profoundly affect HIV replication in T lymphocytes and MPs in vitro. Because many of these cytokines have been found to be elevated in HIV-infected individuals, it is likely that they act as regulators of viral expression in vivo. Both viral genes and cytokines regulate transcriptional and posttranscriptional steps in HIV replication. Thus, it is likely that common regulatory pathways between these two distinct classes of regulator molecules will be identified in the near future and will provide potential targets for pharmacologic intervention and treatment of HIV disease.

AB - The human immunodeficiency virus (HIV) is the causative agent of the acquired immunodeficiency syndrome (AIDS), a leading cause of death among young individuals. As a complex pathogenic retrovirus, HIV is characterized in vitro and in vivo by the ability to establish either a latent or productive infection of CD4+ T lymphocytes and mononuclear phagocytes (MPs). Viral latency and expression are under the control of both viral genes and several host-related factors. Among these latter, several proinflammatory and immunoregulatory cytokines profoundly affect HIV replication in T lymphocytes and MPs in vitro. Because many of these cytokines have been found to be elevated in HIV-infected individuals, it is likely that they act as regulators of viral expression in vivo. Both viral genes and cytokines regulate transcriptional and posttranscriptional steps in HIV replication. Thus, it is likely that common regulatory pathways between these two distinct classes of regulator molecules will be identified in the near future and will provide potential targets for pharmacologic intervention and treatment of HIV disease.

KW - cytokines

KW - genes

KW - HIV

KW - latency

KW - pathogenesis

UR - http://www.scopus.com/inward/record.url?scp=0027993759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027993759&partnerID=8YFLogxK

M3 - Article

C2 - 8083604

AN - SCOPUS:0027993759

VL - 56

SP - 328

EP - 334

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 3

ER -