Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction

Aurore Brémond, Ophélie Meynet, Karim Mahiddine, Sylvie Coito, Mélanie Tichet, Katia Scotlandi, Jean Philippe Breittmayer, Pierre Gounon, Paul A. Gleeson, Alain Bernard, Ghislaine Bernard

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

By presenting antigenic peptides on the cell surface, human leukocyte antigen (HLA) class I molecules are critical for immune defense. Their surface density determines, to a large extent, the level of CD8+ T cell-dependent immune reactions; their loss is a major mechanism of immune escape. Therefore, powerful processes should regulate their surface expression. Here we document the mechanisms used by CD99 to mediate HLA class I modulation. Up-regulation of HLA class I by IFN-7 requires CD99. In the trans Golgi network (TGN), and up to the cell surface, CD99 and HLA class I are physically associated via their transmembrane domain. CD99 also binds p230/ golgin-245, a coiled-coil protein that recycles between the cytosol and buds/ vesicles of the TGN and which plays a fundamental role in trafficking transport vesicles. p230/golgin-245 is anchored within TGN membranes via its Golgin-97, RanBP1, IMh1p, P230 (GRIP) domain and the overexpression of which leads to surface and intracellular down-modulation of HLA class I molecules.

Original languageEnglish
Pages (from-to)347-357
Number of pages11
JournalBlood
Volume113
Issue number2
DOIs
Publication statusPublished - Jan 8 2009

Fingerprint

HLA Antigens
trans-Golgi Network
Antigen-antibody reactions
Modulation
Transport Vesicles
Molecules
T-cells
Cytosol
Up-Regulation
p 230
Membranes
T-Lymphocytes
Peptides
Proteins

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Brémond, A., Meynet, O., Mahiddine, K., Coito, S., Tichet, M., Scotlandi, K., ... Bernard, G. (2009). Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction. Blood, 113(2), 347-357. https://doi.org/10.1182/blood-2008-02-137745

Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction. / Brémond, Aurore; Meynet, Ophélie; Mahiddine, Karim; Coito, Sylvie; Tichet, Mélanie; Scotlandi, Katia; Breittmayer, Jean Philippe; Gounon, Pierre; Gleeson, Paul A.; Bernard, Alain; Bernard, Ghislaine.

In: Blood, Vol. 113, No. 2, 08.01.2009, p. 347-357.

Research output: Contribution to journalArticle

Brémond, A, Meynet, O, Mahiddine, K, Coito, S, Tichet, M, Scotlandi, K, Breittmayer, JP, Gounon, P, Gleeson, PA, Bernard, A & Bernard, G 2009, 'Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction', Blood, vol. 113, no. 2, pp. 347-357. https://doi.org/10.1182/blood-2008-02-137745
Brémond, Aurore ; Meynet, Ophélie ; Mahiddine, Karim ; Coito, Sylvie ; Tichet, Mélanie ; Scotlandi, Katia ; Breittmayer, Jean Philippe ; Gounon, Pierre ; Gleeson, Paul A. ; Bernard, Alain ; Bernard, Ghislaine. / Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction. In: Blood. 2009 ; Vol. 113, No. 2. pp. 347-357.
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