Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor

Barbara Belletti, Robert Drakas, Andrea Morrione, Xiao Tu, Marco Prisco, Tina Yuan, Ivan Casaburi, Renato Baserga

Research output: Contribution to journalArticle

Abstract

The activated type 1 insulin-like growth factor (IGF-IR) increases the expression of Id1 proteins in mouse embryo fibroblasts (MEF). Up-regulation depends on a functional receptor and on multiple pathways originating from different domains of the receptor. In MEF, Id1 protein expression is also up-regulated by serum and certain oncogenes. Signaling through Stat3 plays an important, but not exclusive, role in the up-regulation of Id1 protein levels. In all instances, the increase in Id1 protein expression is paralleled by a corresponding increase in Id1 promoter activity, as measured with a reporter gene.

Original languageEnglish
Pages (from-to)107-118
Number of pages12
JournalExperimental Cell Research
Volume277
Issue number1
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Cell Biology

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