Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor

Barbara Belletti, Robert Drakas, Andrea Morrione, Xiao Tu, Marco Prisco, Tina Yuan, Ivan Casaburi, Renato Baserga

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The activated type 1 insulin-like growth factor (IGF-IR) increases the expression of Id1 proteins in mouse embryo fibroblasts (MEF). Up-regulation depends on a functional receptor and on multiple pathways originating from different domains of the receptor. In MEF, Id1 protein expression is also up-regulated by serum and certain oncogenes. Signaling through Stat3 plays an important, but not exclusive, role in the up-regulation of Id1 protein levels. In all instances, the increase in Id1 protein expression is paralleled by a corresponding increase in Id1 promoter activity, as measured with a reporter gene.

Original languageEnglish
Pages (from-to)107-118
Number of pages12
JournalExperimental Cell Research
Volume277
Issue number1
DOIs
Publication statusPublished - 2002

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IGF Type 1 Receptor
Embryonic Structures
Fibroblasts
Up-Regulation
Proteins
Somatomedins
Reporter Genes
Oncogenes
Serum

ASJC Scopus subject areas

  • Cell Biology

Cite this

Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. / Belletti, Barbara; Drakas, Robert; Morrione, Andrea; Tu, Xiao; Prisco, Marco; Yuan, Tina; Casaburi, Ivan; Baserga, Renato.

In: Experimental Cell Research, Vol. 277, No. 1, 2002, p. 107-118.

Research output: Contribution to journalArticle

Belletti, Barbara ; Drakas, Robert ; Morrione, Andrea ; Tu, Xiao ; Prisco, Marco ; Yuan, Tina ; Casaburi, Ivan ; Baserga, Renato. / Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor. In: Experimental Cell Research. 2002 ; Vol. 277, No. 1. pp. 107-118.
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