Regulation of immune responses by L-arginine metabolism

Vincenzo Bronte, Paola Zanovello

Research output: Contribution to journalArticlepeer-review

Abstract

L-Arginine is an essential amino acid for birds and young mammals, and it is a conditionally essential amino acid for adult mammals, as it is important in situations in which requirements exceed production, such as pregnancy. Recent findings indicate that increased metabolism of L-arginine by myeloid cells can result in the impairment of lymphocyte responses to antigen during immune responses and tumour growth. Two enzymes that compete for L-arginine as a substrate - arginase and nitric-oxide synthase - are crucial components of this lymphocyte-suppression pathway, and the metabolic products of these enzymes are important moderators of T-cell function. This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions.

Original languageEnglish
Pages (from-to)641-654
Number of pages14
JournalNature Reviews Immunology
Volume5
Issue number8
DOIs
Publication statusPublished - Aug 2005

ASJC Scopus subject areas

  • Immunology

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