Regulation of inhibitory pathways of the interleukin-1 system

A. Mantovani, M. Muzio, P. Ghezzi, C. Colotta, M. Introna

Research output: Contribution to journalArticle

Abstract

The IL-1 system includes two agonists, converting enzymes, antagonists, and two receptors (R). New elements and functions in the system will be discussed, including (a) cloning of a new isoform of the receptor antagonist; (b) further analysis of the type II IL-1-binding molecule as a decoy R. The modulation of IL-1R by chemotactic signals was recently investigated. It was found that chemoattractants cause rapid release of the type II decoy R from myelomonocytic cells with a t(1/2) of 30 sec. Induction of decoy R release represents an early event in the multistep process of recruitment. It may serve to block the systemic action of IL-1 leaking from sites of inflammation, while preserving responsiveness in situ. We recently cloned the first long pentraxin, PTX3 (human and mouse, cDNA and genomic) as an IL-1-inducible gene. The structural and functional features of this molecule as well as initial evidence of involvement in human pathology will be discussed.

Original languageEnglish
Pages (from-to)338-351
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume840
DOIs
Publication statusPublished - May 1 1998

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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