TY - JOUR
T1 - Regulation of integrins by conformation and traffic
T2 - It takes two to tango
AU - Valdembri, Donatella
AU - Sandri, Chiara
AU - Santambrogio, Martina
AU - Serini, Guido
PY - 2011/9/1
Y1 - 2011/9/1
N2 - In multicellular organisms, the execution of complex morphogenetic events, such as gastrulation or vascular morphogenesis, depends on the dynamic modulation of adhesion. Guidance cues, such as chemokines, growth factors, and semaphorins control the attachment of cells to extracellular matrix proteins by regulating the conformational activation of integrin receptors. The endo-exocytic traffic of integrins back and forth from the plasma membrane represents another crucial regulatory aspect in cell adhesion and motility. Recent work added an additional layer of complexity by indicating that distinct molecular machineries are required for trafficking active and inactive integrins.
AB - In multicellular organisms, the execution of complex morphogenetic events, such as gastrulation or vascular morphogenesis, depends on the dynamic modulation of adhesion. Guidance cues, such as chemokines, growth factors, and semaphorins control the attachment of cells to extracellular matrix proteins by regulating the conformational activation of integrin receptors. The endo-exocytic traffic of integrins back and forth from the plasma membrane represents another crucial regulatory aspect in cell adhesion and motility. Recent work added an additional layer of complexity by indicating that distinct molecular machineries are required for trafficking active and inactive integrins.
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U2 - 10.1039/c1mb05066d
DO - 10.1039/c1mb05066d
M3 - Article
C2 - 21761076
AN - SCOPUS:80051742457
VL - 7
SP - 2539
EP - 2546
JO - Molecular BioSystems
JF - Molecular BioSystems
SN - 1742-206X
IS - 9
ER -