Regulation of integrins by conformation and traffic: It takes two to tango

Donatella Valdembri, Chiara Sandri, Martina Santambrogio, Guido Serini

Research output: Contribution to journalArticlepeer-review

Abstract

In multicellular organisms, the execution of complex morphogenetic events, such as gastrulation or vascular morphogenesis, depends on the dynamic modulation of adhesion. Guidance cues, such as chemokines, growth factors, and semaphorins control the attachment of cells to extracellular matrix proteins by regulating the conformational activation of integrin receptors. The endo-exocytic traffic of integrins back and forth from the plasma membrane represents another crucial regulatory aspect in cell adhesion and motility. Recent work added an additional layer of complexity by indicating that distinct molecular machineries are required for trafficking active and inactive integrins.

Original languageEnglish
Pages (from-to)2539-2546
Number of pages8
JournalMolecular BioSystems
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 1 2011

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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