Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency

Armin Finkenstedt, Paola Bianchi, Igor Theurl, Wolfgang Vogel, Derrick R. Witcher, Victor J. Wroblewski, Anthony T. Murphy, Alberto Zanella, Heinz Zoller

Research output: Contribution to journalArticle

Abstract

Iron absorption is inadequately increased in patients with chronic haemolytic anaemia, which is commonly complicated by iron overload. Growth differentiation factor 15 (GDF15) has been identified as a bone marrow-derived factor that abrogates hepcidin-mediated protection from iron overload under conditions of increased erythropoiesis. Increased concentrations of GDF15 have been reported in β-thalassaemia patients and GDF15 has been found to suppress hepcidin expression in vitro. To further study the interdependencies of iron metabolism and erythropoiesis in vivo, the concentrations of hepcidin and GDF15 were determined in sera from 22 patients with pyruvate kinase deficiency (PKD) and 21 healthy control subjects. In PKD patients, serum hepcidin levels were 13-fold lower than in controls (2.0 ng/ml vs. 26.2 ng/ml) and GDF15 was significantly higher (859 pg/ml vs. 528 pg/ml). Serum hepcidin concentrations correlated positively with haemoglobin and negatively with serum GDF15. These results suggest that GDF15 contributes to low hepcidin expression and iron loading in PKD.

Original languageEnglish
Pages (from-to)789-793
Number of pages5
JournalBritish Journal of Haematology
Volume144
Issue number5
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Anaemia
  • GDF15
  • Hepcidin
  • Iron
  • Pyruvate kinase deficiency

ASJC Scopus subject areas

  • Hematology

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    Finkenstedt, A., Bianchi, P., Theurl, I., Vogel, W., Witcher, D. R., Wroblewski, V. J., Murphy, A. T., Zanella, A., & Zoller, H. (2009). Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency. British Journal of Haematology, 144(5), 789-793. https://doi.org/10.1111/j.1365-2141.2008.07535.x