Regulation of JAK3 expression in human monocytes: Phosphorylation in response to interleukins 2, 4, and 7

Tiziana Musso, James A. Johnston, Diana Linnekin, Luigi Varesio, Tammy K. Rowe, John J. O'Shea, Daniel W. McVicar

Research output: Contribution to journalArticlepeer-review

Abstract

The Janus family of kinases (JAKs) has been shown to be involved in the signal transduction of a number of cytokine receptors. Recently, we have cloned a novel JAK family member, JAK3, that is expressed in natural killer and activated T cells and is coupled functionally and physically to the interleukin 2 (IL-2) receptor in these cells. Here we report that JAK3 was expressed at low but detectable levels in human monocytes. In contrast, JAK3 expression was strongly induced during activation by interferon γ (IFN-γ) or lipopolysaccharide. Moreover, JAK3 became tyrosine phosphorylated in response to IL-2, IL-4, and IL-7 but not response to IFN-γ or granulocyte/macrophage colony-stimulating factor. Together, these findings suggest that JAK3 is functionally important in activated monocytes and cells of the myeloid lineage and is involved in signaling responses of cytokines that use the common γ-chain of the IL-2 receptor.

Original languageEnglish
Pages (from-to)1425-1431
Number of pages7
JournalJournal of Experimental Medicine
Volume181
Issue number4
DOIs
Publication statusPublished - Apr 1 1995

ASJC Scopus subject areas

  • Immunology

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