Regulation of KIR expression in human T cells: A safety mechanism that may impair protective T-cell responses

Maria Cristina Mingari; Alessandro Moretta; Lorenzo Moretta

doi:10.1016/S0167-5699(97)01236-X

Regulation of KIR expression in human T cells: A safety mechanism that may impair protective T-cell responses

Maria Cristina Mingari, Alessandro Moretta, Lorenzo Moretta

Research output: Contribution to journal › Article › peer-review

Abstract

Killer-cell inhibitory receptors (KIRs) are a new family of major histocompatibility complex (MHC) class I-specific receptors. KIRs allow natural killer cells to identify and lyse self cells that do not express sufficient amounts of MHC class I molecules. Here, Maria Cristina Mingari and colleagues view the expression of KIRs by cytolytic T lymphocytes and their regulation by certain cytokines as a double-edged sword.

Original language	English
Pages (from-to)	153-156
Number of pages	4
Journal	Immunology Today
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/S0167-5699(97)01236-X
Publication status	Published - Apr 1 1998

ASJC Scopus subject areas

Immunology

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abstract = "Killer-cell inhibitory receptors (KIRs) are a new family of major histocompatibility complex (MHC) class I-specific receptors. KIRs allow natural killer cells to identify and lyse self cells that do not express sufficient amounts of MHC class I molecules. Here, Maria Cristina Mingari and colleagues view the expression of KIRs by cytolytic T lymphocytes and their regulation by certain cytokines as a double-edged sword.",

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