Regulation of KIR expression in human T cells: A safety mechanism that may impair protective T-cell responses

Research output: Contribution to journalArticlepeer-review

Abstract

Killer-cell inhibitory receptors (KIRs) are a new family of major histocompatibility complex (MHC) class I-specific receptors. KIRs allow natural killer cells to identify and lyse self cells that do not express sufficient amounts of MHC class I molecules. Here, Maria Cristina Mingari and colleagues view the expression of KIRs by cytolytic T lymphocytes and their regulation by certain cytokines as a double-edged sword.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalImmunology Today
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 1 1998

ASJC Scopus subject areas

  • Immunology

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