Regulation of leukocyte recruitment by the long pentraxin PTX3

Livija Deban, Remo Castro Russo, Marina Sironi, Federica Moalli, Margherita Scanziani, Vanessa Zambelli, Ivan Cuccovillo, Antonio Bastone, Marco Gobbi, Sonia Valentino, Andrea Doni, Cecilia Garlanda, Silvio Danese, Giovanni Salvatori, Marica Sassano, Virgilio Evangelista, Barbara Rossi, Elena Zenaro, Gabriela Constantin, Carlo LaudannaBarbara Bottazzi, Alberto Mantovani

Research output: Contribution to journalArticle

274 Citations (Scopus)

Abstract

Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.

Original languageEnglish
Pages (from-to)328-334
Number of pages7
JournalNature Immunology
Volume11
Issue number4
DOIs
Publication statusPublished - 2010

Fingerprint

Leukocytes
Inflammation
Innate Immunity
Neutrophil Infiltration
Glycosylation
Acute-Phase Reaction
P-Selectin
Complement Activation
Humoral Immunity
Immunoglobulins
PTX3 protein
Antibodies
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Regulation of leukocyte recruitment by the long pentraxin PTX3. / Deban, Livija; Russo, Remo Castro; Sironi, Marina; Moalli, Federica; Scanziani, Margherita; Zambelli, Vanessa; Cuccovillo, Ivan; Bastone, Antonio; Gobbi, Marco; Valentino, Sonia; Doni, Andrea; Garlanda, Cecilia; Danese, Silvio; Salvatori, Giovanni; Sassano, Marica; Evangelista, Virgilio; Rossi, Barbara; Zenaro, Elena; Constantin, Gabriela; Laudanna, Carlo; Bottazzi, Barbara; Mantovani, Alberto.

In: Nature Immunology, Vol. 11, No. 4, 2010, p. 328-334.

Research output: Contribution to journalArticle

Deban, L, Russo, RC, Sironi, M, Moalli, F, Scanziani, M, Zambelli, V, Cuccovillo, I, Bastone, A, Gobbi, M, Valentino, S, Doni, A, Garlanda, C, Danese, S, Salvatori, G, Sassano, M, Evangelista, V, Rossi, B, Zenaro, E, Constantin, G, Laudanna, C, Bottazzi, B & Mantovani, A 2010, 'Regulation of leukocyte recruitment by the long pentraxin PTX3', Nature Immunology, vol. 11, no. 4, pp. 328-334. https://doi.org/10.1038/ni.1854
Deban L, Russo RC, Sironi M, Moalli F, Scanziani M, Zambelli V et al. Regulation of leukocyte recruitment by the long pentraxin PTX3. Nature Immunology. 2010;11(4):328-334. https://doi.org/10.1038/ni.1854
Deban, Livija ; Russo, Remo Castro ; Sironi, Marina ; Moalli, Federica ; Scanziani, Margherita ; Zambelli, Vanessa ; Cuccovillo, Ivan ; Bastone, Antonio ; Gobbi, Marco ; Valentino, Sonia ; Doni, Andrea ; Garlanda, Cecilia ; Danese, Silvio ; Salvatori, Giovanni ; Sassano, Marica ; Evangelista, Virgilio ; Rossi, Barbara ; Zenaro, Elena ; Constantin, Gabriela ; Laudanna, Carlo ; Bottazzi, Barbara ; Mantovani, Alberto. / Regulation of leukocyte recruitment by the long pentraxin PTX3. In: Nature Immunology. 2010 ; Vol. 11, No. 4. pp. 328-334.
@article{998a5470b8da47dbb0416dc1513dbe53,
title = "Regulation of leukocyte recruitment by the long pentraxin PTX3",
abstract = "Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.",
author = "Livija Deban and Russo, {Remo Castro} and Marina Sironi and Federica Moalli and Margherita Scanziani and Vanessa Zambelli and Ivan Cuccovillo and Antonio Bastone and Marco Gobbi and Sonia Valentino and Andrea Doni and Cecilia Garlanda and Silvio Danese and Giovanni Salvatori and Marica Sassano and Virgilio Evangelista and Barbara Rossi and Elena Zenaro and Gabriela Constantin and Carlo Laudanna and Barbara Bottazzi and Alberto Mantovani",
year = "2010",
doi = "10.1038/ni.1854",
language = "English",
volume = "11",
pages = "328--334",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Regulation of leukocyte recruitment by the long pentraxin PTX3

AU - Deban, Livija

AU - Russo, Remo Castro

AU - Sironi, Marina

AU - Moalli, Federica

AU - Scanziani, Margherita

AU - Zambelli, Vanessa

AU - Cuccovillo, Ivan

AU - Bastone, Antonio

AU - Gobbi, Marco

AU - Valentino, Sonia

AU - Doni, Andrea

AU - Garlanda, Cecilia

AU - Danese, Silvio

AU - Salvatori, Giovanni

AU - Sassano, Marica

AU - Evangelista, Virgilio

AU - Rossi, Barbara

AU - Zenaro, Elena

AU - Constantin, Gabriela

AU - Laudanna, Carlo

AU - Bottazzi, Barbara

AU - Mantovani, Alberto

PY - 2010

Y1 - 2010

N2 - Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.

AB - Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.

UR - http://www.scopus.com/inward/record.url?scp=77949782407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949782407&partnerID=8YFLogxK

U2 - 10.1038/ni.1854

DO - 10.1038/ni.1854

M3 - Article

C2 - 20208538

AN - SCOPUS:77949782407

VL - 11

SP - 328

EP - 334

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 4

ER -