Regulation of low density lipoprotein metabolism by 26-hydroxycholesterol in human fibroblasts

José L. Lorenzo, Maria Allorio, Franco Bernini, Alberto Corsini, Remo Fumagalli

Research output: Contribution to journalArticlepeer-review

Abstract

Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed-back control of its biosynthesis. We report that 26-hydroxycholesterol inhibits the specific binding, uptake and degradation of 125I-LDL in human fibroblasts. The effect is dose-dependent, and saturation kinetics indicates a reduction of LDL-binding sites with no effect on ligand affinity. The results support a possible role of 26-hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalFEBS Letters
Volume218
Issue number1
DOIs
Publication statusPublished - Jun 22 1987

Keywords

  • (Human fibroblast)
  • 26-Hydroxycholesterol
  • LDL
  • LDL receptor
  • Oxysterol

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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