Regulation of macrophage function in tumors: The multifaceted role of NF-κB

Thorsten Hagemann, Subhra K. Biswas, Toby Lawrence, Antonio Sica, Claire E. Lewis

Research output: Contribution to journalArticle

Abstract

The pivotal role of tumor-associated macrophages (TAMs) in tumor progression is now well established. TAMs have been shown to influence multiple steps in tumor development including the growth, survival, invasion, and metastasis of tumor cells as well as angiogenesis and lymphangiogenesis in tumors. The molecular circuits that polarize TAMs toward such a protumoral phenotype are now the focus of intense investigation. The transcription factor, nuclear factor-κB (NF- κB), is a master regulator of many cellular processes and been shown to regulate various pathways that impact on the function of TAMs. Much evidence for this has come from the use of elegant transgenic murine tumor models in which modification of single components of the NF-κB signaling pathway has been shown to regulate the pro-tumor repertoire of TAMs. Here, we outline this evidence and attempt to reconcile the various views that have emerged recently over the exact role of NF-κB in this phenomenon.

Original languageEnglish
Pages (from-to)3139-3146
Number of pages8
JournalBlood
Volume113
Issue number14
DOIs
Publication statusPublished - Apr 2 2009

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ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Hagemann, T., Biswas, S. K., Lawrence, T., Sica, A., & Lewis, C. E. (2009). Regulation of macrophage function in tumors: The multifaceted role of NF-κB. Blood, 113(14), 3139-3146. https://doi.org/10.1182/blood-2008-12-172825