Regulation of male fertility by the endocannabinoid system

Natalia Battista, Cinzia Rapino, Monia Di Tommaso, Monica Bari, Nicoletta Pasquariello, Mauro Maccarrone

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Mammalian conception is a complex process regulated by both sexual behavior and reproductive performance. Alcohol, marijuana and tobacco are among the main factors which affect negatively fertility in women and men. Several studies have demonstrated that marijuana impairs the male copulatory activity, and that smokers of this illegal drug show reduced fertility due, for instance, to decrease in sperm concentration, defective sperm function or alteration of sperm morphology. The discovery of endocannabinoids and all components responsible for their metabolism has allowed to collect valuable information on the effects of these endogenous lipids, able to mimic the actions of delta-9-tetrahydrocannabinol (THC), in reproductive functions. The purpose of this review is to describe the actions of cannabinoids and endocannabinoids on the control of procreation and hormonal release during the fertilization process in males.

Original languageEnglish
JournalMolecular and Cellular Endocrinology
Volume286
Issue number1-2 SUPPL. 1
DOIs
Publication statusPublished - Apr 16 2008

Fingerprint

Endocannabinoids
Cannabis
Fertility
Spermatozoa
Dronabinol
Tobacco
Cannabinoids
Metabolism
Alcohols
Lipids
Fertilization
Sexual Behavior
Pharmaceutical Preparations

Keywords

  • Endocannabinoids
  • Fertility
  • Hormones
  • Sperm cells
  • Testis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Regulation of male fertility by the endocannabinoid system. / Battista, Natalia; Rapino, Cinzia; Di Tommaso, Monia; Bari, Monica; Pasquariello, Nicoletta; Maccarrone, Mauro.

In: Molecular and Cellular Endocrinology, Vol. 286, No. 1-2 SUPPL. 1, 16.04.2008.

Research output: Contribution to journalArticle

Battista, N, Rapino, C, Di Tommaso, M, Bari, M, Pasquariello, N & Maccarrone, M 2008, 'Regulation of male fertility by the endocannabinoid system', Molecular and Cellular Endocrinology, vol. 286, no. 1-2 SUPPL. 1. https://doi.org/10.1016/j.mce.2008.01.010
Battista, Natalia ; Rapino, Cinzia ; Di Tommaso, Monia ; Bari, Monica ; Pasquariello, Nicoletta ; Maccarrone, Mauro. / Regulation of male fertility by the endocannabinoid system. In: Molecular and Cellular Endocrinology. 2008 ; Vol. 286, No. 1-2 SUPPL. 1.
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