Regulation of male fertility by the endocannabinoid system

Natalia Battista; Cinzia Rapino; Monia Di Tommaso; Monica Bari; Nicoletta Pasquariello; Mauro Maccarrone

doi:10.1016/j.mce.2008.01.010

Regulation of male fertility by the endocannabinoid system

Natalia Battista, Cinzia Rapino, Monia Di Tommaso, Monica Bari, Nicoletta Pasquariello, Mauro Maccarrone

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Mammalian conception is a complex process regulated by both sexual behavior and reproductive performance. Alcohol, marijuana and tobacco are among the main factors which affect negatively fertility in women and men. Several studies have demonstrated that marijuana impairs the male copulatory activity, and that smokers of this illegal drug show reduced fertility due, for instance, to decrease in sperm concentration, defective sperm function or alteration of sperm morphology. The discovery of endocannabinoids and all components responsible for their metabolism has allowed to collect valuable information on the effects of these endogenous lipids, able to mimic the actions of delta-9-tetrahydrocannabinol (THC), in reproductive functions. The purpose of this review is to describe the actions of cannabinoids and endocannabinoids on the control of procreation and hormonal release during the fertilization process in males.

Original language	English
Journal	Molecular and Cellular Endocrinology
Volume	286
Issue number	1-2 SUPPL. 1
DOIs	https://doi.org/10.1016/j.mce.2008.01.010
Publication status	Published - Apr 16 2008

Keywords

Endocannabinoids
Fertility
Hormones
Sperm cells
Testis

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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abstract = "Mammalian conception is a complex process regulated by both sexual behavior and reproductive performance. Alcohol, marijuana and tobacco are among the main factors which affect negatively fertility in women and men. Several studies have demonstrated that marijuana impairs the male copulatory activity, and that smokers of this illegal drug show reduced fertility due, for instance, to decrease in sperm concentration, defective sperm function or alteration of sperm morphology. The discovery of endocannabinoids and all components responsible for their metabolism has allowed to collect valuable information on the effects of these endogenous lipids, able to mimic the actions of delta-9-tetrahydrocannabinol (THC), in reproductive functions. The purpose of this review is to describe the actions of cannabinoids and endocannabinoids on the control of procreation and hormonal release during the fertilization process in males.",

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AU - Di Tommaso, Monia

AU - Bari, Monica

AU - Pasquariello, Nicoletta

AU - Maccarrone, Mauro

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