Regulation of muscle acetylcholine receptor-channel function by interferon

Fabrizio Eusebi; Donatella Farini; Francesca Grassi; Angela Santoni

doi:10.1007/BF00370585

Regulation of muscle acetylcholine receptor-channel function by interferon

Fabrizio Eusebi, Donatella Farini, Francesca Grassi, Angela Santoni

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Abstract

The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.

Original language	English
Pages (from-to)	150-155
Number of pages	6
Journal	Pflugers Archiv European Journal of Physiology
Volume	415
Issue number	2
DOIs	https://doi.org/10.1007/BF00370585
Publication status	Published - Nov 1989

Keywords

Acetylcholine receptor
Interferon
Muscle fibre

ASJC Scopus subject areas

Physiology

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abstract = "The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.",

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AU - Eusebi, Fabrizio

AU - Farini, Donatella

AU - Grassi, Francesca

AU - Santoni, Angela

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