Regulation of muscle acetylcholine receptor-channel function by interferon

Fabrizio Eusebi, Donatella Farini, Francesca Grassi, Angela Santoni

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalPflugers Archiv European Journal of Physiology
Volume415
Issue number2
DOIs
Publication statusPublished - Nov 1989

Keywords

  • Acetylcholine receptor
  • Interferon
  • Muscle fibre

ASJC Scopus subject areas

  • Physiology

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