Regulation of muscle acetylcholine receptor-channel function by interferon

Fabrizio Eusebi, Donatella Farini, Francesca Grassi, Angela Santoni

Research output: Contribution to journalArticle

Abstract

The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.

Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalPflugers Archiv European Journal of Physiology
Volume415
Issue number2
DOIs
Publication statusPublished - Nov 1989

Fingerprint

Cholinergic Receptors
Interferons
Muscle
Muscles
Skeletal Muscle Fibers
Fibers
Interferon-beta
Clamping devices
Nicotinic Receptors
Interferon-alpha
Antiviral Agents
Rats
Patch-Clamp Techniques

Keywords

  • Acetylcholine receptor
  • Interferon
  • Muscle fibre

ASJC Scopus subject areas

  • Physiology

Cite this

Regulation of muscle acetylcholine receptor-channel function by interferon. / Eusebi, Fabrizio; Farini, Donatella; Grassi, Francesca; Santoni, Angela.

In: Pflugers Archiv European Journal of Physiology, Vol. 415, No. 2, 11.1989, p. 150-155.

Research output: Contribution to journalArticle

Eusebi, Fabrizio ; Farini, Donatella ; Grassi, Francesca ; Santoni, Angela. / Regulation of muscle acetylcholine receptor-channel function by interferon. In: Pflugers Archiv European Journal of Physiology. 1989 ; Vol. 415, No. 2. pp. 150-155.
@article{ff8db1aceab34d33b5cc9e58d679f47f,
title = "Regulation of muscle acetylcholine receptor-channel function by interferon",
abstract = "The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.",
keywords = "Acetylcholine receptor, Interferon, Muscle fibre",
author = "Fabrizio Eusebi and Donatella Farini and Francesca Grassi and Angela Santoni",
year = "1989",
month = "11",
doi = "10.1007/BF00370585",
language = "English",
volume = "415",
pages = "150--155",
journal = "Pflugers Archiv European Journal of Physiology",
issn = "0031-6768",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Regulation of muscle acetylcholine receptor-channel function by interferon

AU - Eusebi, Fabrizio

AU - Farini, Donatella

AU - Grassi, Francesca

AU - Santoni, Angela

PY - 1989/11

Y1 - 1989/11

N2 - The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.

AB - The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.

KW - Acetylcholine receptor

KW - Interferon

KW - Muscle fibre

UR - http://www.scopus.com/inward/record.url?scp=0024342637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024342637&partnerID=8YFLogxK

U2 - 10.1007/BF00370585

DO - 10.1007/BF00370585

M3 - Article

C2 - 2480577

AN - SCOPUS:0024342637

VL - 415

SP - 150

EP - 155

JO - Pflugers Archiv European Journal of Physiology

JF - Pflugers Archiv European Journal of Physiology

SN - 0031-6768

IS - 2

ER -