Abstract
The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.
| Original language | English |
|---|---|
| Pages (from-to) | 150-155 |
| Number of pages | 6 |
| Journal | Pflugers Archiv European Journal of Physiology |
| Volume | 415 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 1989 |
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Keywords
- Acetylcholine receptor
- Interferon
- Muscle fibre
ASJC Scopus subject areas
- Physiology
Cite this
Regulation of muscle acetylcholine receptor-channel function by interferon. / Eusebi, Fabrizio; Farini, Donatella; Grassi, Francesca; Santoni, Angela.
In: Pflugers Archiv European Journal of Physiology, Vol. 415, No. 2, 11.1989, p. 150-155.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of muscle acetylcholine receptor-channel function by interferon
AU - Eusebi, Fabrizio
AU - Farini, Donatella
AU - Grassi, Francesca
AU - Santoni, Angela
PY - 1989/11
Y1 - 1989/11
N2 - The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.
AB - The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-β) in the mouse myotubes, and with IFN-β and leucocytes IFN (IFN-α), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.
KW - Acetylcholine receptor
KW - Interferon
KW - Muscle fibre
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UR - http://www.scopus.com/inward/citedby.url?scp=0024342637&partnerID=8YFLogxK
U2 - 10.1007/BF00370585
DO - 10.1007/BF00370585
M3 - Article
C2 - 2480577
AN - SCOPUS:0024342637
VL - 415
SP - 150
EP - 155
JO - Pflugers Archiv European Journal of Physiology
JF - Pflugers Archiv European Journal of Physiology
SN - 0031-6768
IS - 2
ER -