Abstract
Skeletal muscle differentiation is influenced by multiple pathways, which regulate the activity of myogenic regulatory factors (MRFs) - the myogenic basic helix-loop-helix proteins and the MEF2-family members - in positive or negative ways. Here we will review and discuss the network of signals that regulate MRF function during myocyte proliferation, differentiation, and post-mitotic growth. Elucidating the mechanisms governing muscle-specific transcription will provide important insight in better understanding the embryonic development of muscle at the molecular level and will have important implications in setting out strategies aimed at muscle regeneration. Since the activity of MRFs are compromised in tumors of myogenic derivation - the rhabdomyosarcomas - the studies summarized in this review can provide a useful tool to uncover the molecular basis underlying the formation of these tumors. (C) 2000 Wiley-Liss, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 155-173 |
| Number of pages | 19 |
| Journal | Journal of Cellular Physiology |
| Volume | 185 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2000 |
Fingerprint
ASJC Scopus subject areas
- Cell Biology
- Clinical Biochemistry
- Physiology
Cite this
Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications. / Puri, Pier Lorenzo; Sartorelli, Vittorio.
In: Journal of Cellular Physiology, Vol. 185, No. 2, 2000, p. 155-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications
AU - Puri, Pier Lorenzo
AU - Sartorelli, Vittorio
PY - 2000
Y1 - 2000
N2 - Skeletal muscle differentiation is influenced by multiple pathways, which regulate the activity of myogenic regulatory factors (MRFs) - the myogenic basic helix-loop-helix proteins and the MEF2-family members - in positive or negative ways. Here we will review and discuss the network of signals that regulate MRF function during myocyte proliferation, differentiation, and post-mitotic growth. Elucidating the mechanisms governing muscle-specific transcription will provide important insight in better understanding the embryonic development of muscle at the molecular level and will have important implications in setting out strategies aimed at muscle regeneration. Since the activity of MRFs are compromised in tumors of myogenic derivation - the rhabdomyosarcomas - the studies summarized in this review can provide a useful tool to uncover the molecular basis underlying the formation of these tumors. (C) 2000 Wiley-Liss, Inc.
AB - Skeletal muscle differentiation is influenced by multiple pathways, which regulate the activity of myogenic regulatory factors (MRFs) - the myogenic basic helix-loop-helix proteins and the MEF2-family members - in positive or negative ways. Here we will review and discuss the network of signals that regulate MRF function during myocyte proliferation, differentiation, and post-mitotic growth. Elucidating the mechanisms governing muscle-specific transcription will provide important insight in better understanding the embryonic development of muscle at the molecular level and will have important implications in setting out strategies aimed at muscle regeneration. Since the activity of MRFs are compromised in tumors of myogenic derivation - the rhabdomyosarcomas - the studies summarized in this review can provide a useful tool to uncover the molecular basis underlying the formation of these tumors. (C) 2000 Wiley-Liss, Inc.
UR - http://www.scopus.com/inward/record.url?scp=0033804899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033804899&partnerID=8YFLogxK
U2 - 10.1002/1097-4652(200011)185:2<155::AID-JCP1>3.0.CO;2-Z
DO - 10.1002/1097-4652(200011)185:2<155::AID-JCP1>3.0.CO;2-Z
M3 - Article
C2 - 11025438
AN - SCOPUS:0033804899
VL - 185
SP - 155
EP - 173
JO - Journal of cellular and comparative physiology
JF - Journal of cellular and comparative physiology
SN - 0021-9541
IS - 2
ER -