Regulation of ovulation rate in mammals: Contribution of sheep genetic models

Stéphane Fabre, Alice Pierre, Philippe Mulsant, Loys Bodin, Elisa Di Pasquale, Luca Persani, Philippe Monget, Danielle Monniaux

Research output: Contribution to journalArticlepeer-review


Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor-9 (GDF-9) and BMP receptor-1B (BMPR-1B). In this review, we focus on the use of these sheep genetic models for understanding the role of the BMP system as an intra-ovarian regulator of follicular growth and maturation, and finally, ovulation rate.

Original languageEnglish
Article number20
JournalReproductive Biology and Endocrinology
Publication statusPublished - Apr 12 2006

ASJC Scopus subject areas

  • Developmental Biology
  • Endocrinology


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