Regulation of ovulation rate in mammals

Contribution of sheep genetic models

Stéphane Fabre, Alice Pierre, Philippe Mulsant, Loys Bodin, Elisa Di Pasquale, Luca Persani, Philippe Monget, Danielle Monniaux

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor-9 (GDF-9) and BMP receptor-1B (BMPR-1B). In this review, we focus on the use of these sheep genetic models for understanding the role of the BMP system as an intra-ovarian regulator of follicular growth and maturation, and finally, ovulation rate.

Original languageEnglish
Article number20
JournalReproductive Biology and Endocrinology
Volume4
DOIs
Publication statusPublished - Apr 12 2006

Fingerprint

Genetic Models
Ovulation
Mammals
Sheep
Bone Morphogenetic Protein 15
Growth Differentiation Factor 9
Bone Morphogenetic Protein Receptors
Constitution and Bylaws
Fertility
Growth
Genes

ASJC Scopus subject areas

  • Developmental Biology
  • Endocrinology

Cite this

Regulation of ovulation rate in mammals : Contribution of sheep genetic models. / Fabre, Stéphane; Pierre, Alice; Mulsant, Philippe; Bodin, Loys; Di Pasquale, Elisa; Persani, Luca; Monget, Philippe; Monniaux, Danielle.

In: Reproductive Biology and Endocrinology, Vol. 4, 20, 12.04.2006.

Research output: Contribution to journalArticle

Fabre, Stéphane ; Pierre, Alice ; Mulsant, Philippe ; Bodin, Loys ; Di Pasquale, Elisa ; Persani, Luca ; Monget, Philippe ; Monniaux, Danielle. / Regulation of ovulation rate in mammals : Contribution of sheep genetic models. In: Reproductive Biology and Endocrinology. 2006 ; Vol. 4.
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