Regulation of progesterone receptor gene expression

E. Vegeto, M. G. Cocciolo, F. Raspagliesi, A. Piffanelli, R. Fontanelli, A. Maggi

Research output: Contribution to journalArticle

Abstract

The levels of progesterone receptor (PR) mRNA, PR protein, and [3H]R5020 binding activity were measured in parallel experiments conducted on a T47D subline expressing the estrogen receptor. A significant increase of PR mRNA levels could be detected within 6 h of exposure of the cells to estradiol (10-8 M). The changes in mRNA, however, did not lead to any variation of PR protein levels of [3H]R5020 binding activity. A parallel analysis of PR mRNA and [3H]R5020 binding was then performed in a series of tumor biopsies. In estrogen receptor-positive and PR-positive tissues a correlation among the two values was found. It is postulated that the above mentioned data could reflect the existence of a difference in the mechanisms controlling the numerous steps of the PR synthesis in the various hormone-responsive tissues. This variability could allow an organ-specific response to the cyclic changes of circulating hormone.

Original languageEnglish
Pages (from-to)5291-5295
Number of pages5
JournalCancer Research
Volume50
Issue number17
Publication statusPublished - Sep 1 1990

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Progesterone Receptors
Gene Expression
Promegestone
Messenger RNA
Estrogen Receptors
Hormones
Estradiol
Proteins
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Vegeto, E., Cocciolo, M. G., Raspagliesi, F., Piffanelli, A., Fontanelli, R., & Maggi, A. (1990). Regulation of progesterone receptor gene expression. Cancer Research, 50(17), 5291-5295.

Regulation of progesterone receptor gene expression. / Vegeto, E.; Cocciolo, M. G.; Raspagliesi, F.; Piffanelli, A.; Fontanelli, R.; Maggi, A.

In: Cancer Research, Vol. 50, No. 17, 01.09.1990, p. 5291-5295.

Research output: Contribution to journalArticle

Vegeto, E, Cocciolo, MG, Raspagliesi, F, Piffanelli, A, Fontanelli, R & Maggi, A 1990, 'Regulation of progesterone receptor gene expression', Cancer Research, vol. 50, no. 17, pp. 5291-5295.
Vegeto E, Cocciolo MG, Raspagliesi F, Piffanelli A, Fontanelli R, Maggi A. Regulation of progesterone receptor gene expression. Cancer Research. 1990 Sep 1;50(17):5291-5295.
Vegeto, E. ; Cocciolo, M. G. ; Raspagliesi, F. ; Piffanelli, A. ; Fontanelli, R. ; Maggi, A. / Regulation of progesterone receptor gene expression. In: Cancer Research. 1990 ; Vol. 50, No. 17. pp. 5291-5295.
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