Regulation of progesterone receptor gene expression

E. Vegeto, M. G. Cocciolo, F. Raspagliesi, A. Piffanelli, R. Fontanelli, A. Maggi

Research output: Contribution to journalArticlepeer-review

Abstract

The levels of progesterone receptor (PR) mRNA, PR protein, and [3H]R5020 binding activity were measured in parallel experiments conducted on a T47D subline expressing the estrogen receptor. A significant increase of PR mRNA levels could be detected within 6 h of exposure of the cells to estradiol (10-8 M). The changes in mRNA, however, did not lead to any variation of PR protein levels of [3H]R5020 binding activity. A parallel analysis of PR mRNA and [3H]R5020 binding was then performed in a series of tumor biopsies. In estrogen receptor-positive and PR-positive tissues a correlation among the two values was found. It is postulated that the above mentioned data could reflect the existence of a difference in the mechanisms controlling the numerous steps of the PR synthesis in the various hormone-responsive tissues. This variability could allow an organ-specific response to the cyclic changes of circulating hormone.

Original languageEnglish
Pages (from-to)5291-5295
Number of pages5
JournalCancer Research
Volume50
Issue number17
Publication statusPublished - Sep 1 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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