Regulation of prostaglandin production by inhibition of poly (ADP- ribose) synthase in carrageenan-induced pleurisy

Salvatore Cuzzocrea, Lidia Sautebin, Giuseppina Costantino, Laura Rombolà, Emanuela Mazzon, Achille P. Caputi

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to investigate the effect of two inhibitors (3-aminobenzamide and nicotinamide) of poly (ADP-ribose) synthetase on the production of the inflammatory mediator prostaglandins in a model of acute inflammation, carrageenan-induced pleurisy, where prostaglandins are known to play a crucial role. The results show that the poly (ADP-ribose) synthetase inhibitors, 3-ami nobenzamide (2.5, 5 and 10 mg/kg) and nicotinamide (12.5, 25 and 50 mg/kg), inhibit the inflammatory response (pleural exudate formation, polymorphonuclear cell infiltration and prostaglandin production). The present results demonstrate that inhibition of poly (ADP-ribose) synthetase exerts potent anti-inflammatory effects. Part of these anti-inflammatory effects may be related to a reduction of prostaglandin production during the inflammatory process.

Original languageEnglish
Pages (from-to)1297-1304
Number of pages8
JournalLife Sciences
Volume65
Issue number12
DOIs
Publication statusPublished - Aug 13 1999

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Keywords

  • Carrageenan-induced pleurisy
  • COX-2
  • PARS
  • Prostaglandins

ASJC Scopus subject areas

  • Pharmacology

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