Regulation of prostaglandin production in carrageenan-induced pleurisy by melatonin

Salvatore Cuzzocrea, Giuseppina Costantino, Emanuela Mazzon, Achille P. Caputi

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to investigate the effect of melatonin on the production of the inflammatory mediator prostaglandins in a model of acute inflammation, carrageenan-induced pleurisy, where prostaglandins are known to play a crucial role. The results show that melatonin (12.5, 25, and 50 mg/kg, intraperitoneally, 15 min before the carrageenan) inhibits the inflammatory response (pleural exudate formation, polymorphonuclear cell infiltration, and prostaglandin production) in a dose-dependent manner. Immunohistochemical examination demonstrated a marked increase in the immunoreactivity to cyclooxygenase-2 (COX-2) in the lungs of carrageenan- treated rats. Pretreatment of carrageenan-treated rats with melatonin (50 mg/kg, intraperitoneally, 15 min before the carrageenan) prevented COX-2 expression. The present results demonstrate that melatonin exerts potent anti-inflammatory effects. Part of these anti-inflammatory effects may be related to a reduction of prostaglandin production during the inflammatory process.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalJournal of Pineal Research
Volume27
Issue number1
DOIs
Publication statusPublished - 1999

Keywords

  • Carrageenan
  • Cyclooxygenase
  • Inflammation
  • Melatonin
  • Prostaglandin

ASJC Scopus subject areas

  • Endocrinology

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