Abstract
Introduction: Previous papers investigating vitamin D status have often outlined the significant relationships between serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD), but the influence of ionized calcium levels has not been concomitantly considered. Design: Cross-sectional. Materials and methods: In 1050 healthy men (547) and women (503), serum ionized calcium (iCa), creatinine (Cr), albumin, 25OHD, and PTH were measured. After conventional analysis, a regression tree was fitted on the data set. Results: 25OHD and PTH values showed significant opposite seasonal changes. 25OHD levels negatively correlated with PTH, which in turn negatively correlated with iCa. A regression tree was fitted to the whole data set using PTH as the response variable and 25OHD and iCa as covariates. PTH concentration depended on that of iCa only in subjects with 25OHD levels>16.35. ng/mL, while for 25OHD
| Original language | English |
|---|---|
| Pages (from-to) | 626-630 |
| Number of pages | 5 |
| Journal | Bone |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2010 |
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Keywords
- 25-Hydroxyvitamin D
- Ionized calcium
- PTH
- Regression tree
ASJC Scopus subject areas
- Physiology
- Endocrinology, Diabetes and Metabolism
- Histology
Cite this
Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status : A study in a large cohort of healthy subjects. / Carnevale, Vincenzo; Nieddu, Luciano; Romagnoli, Elisabetta; Battista, Claudia; Mascia, Maria Lucia; Chiodini, Iacopo; Eller-Vainicher, Cristina; Frusciante, Vincenzo; Santini, Stefano Angelo; La Porta, Michele; Minisola, Salvatore; Scillitani, Alfredo.
In: Bone, Vol. 47, No. 3, 09.2010, p. 626-630.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status
T2 - A study in a large cohort of healthy subjects
AU - Carnevale, Vincenzo
AU - Nieddu, Luciano
AU - Romagnoli, Elisabetta
AU - Battista, Claudia
AU - Mascia, Maria Lucia
AU - Chiodini, Iacopo
AU - Eller-Vainicher, Cristina
AU - Frusciante, Vincenzo
AU - Santini, Stefano Angelo
AU - La Porta, Michele
AU - Minisola, Salvatore
AU - Scillitani, Alfredo
PY - 2010/9
Y1 - 2010/9
N2 - Introduction: Previous papers investigating vitamin D status have often outlined the significant relationships between serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD), but the influence of ionized calcium levels has not been concomitantly considered. Design: Cross-sectional. Materials and methods: In 1050 healthy men (547) and women (503), serum ionized calcium (iCa), creatinine (Cr), albumin, 25OHD, and PTH were measured. After conventional analysis, a regression tree was fitted on the data set. Results: 25OHD and PTH values showed significant opposite seasonal changes. 25OHD levels negatively correlated with PTH, which in turn negatively correlated with iCa. A regression tree was fitted to the whole data set using PTH as the response variable and 25OHD and iCa as covariates. PTH concentration depended on that of iCa only in subjects with 25OHD levels>16.35. ng/mL, while for 25OHD
AB - Introduction: Previous papers investigating vitamin D status have often outlined the significant relationships between serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD), but the influence of ionized calcium levels has not been concomitantly considered. Design: Cross-sectional. Materials and methods: In 1050 healthy men (547) and women (503), serum ionized calcium (iCa), creatinine (Cr), albumin, 25OHD, and PTH were measured. After conventional analysis, a regression tree was fitted on the data set. Results: 25OHD and PTH values showed significant opposite seasonal changes. 25OHD levels negatively correlated with PTH, which in turn negatively correlated with iCa. A regression tree was fitted to the whole data set using PTH as the response variable and 25OHD and iCa as covariates. PTH concentration depended on that of iCa only in subjects with 25OHD levels>16.35. ng/mL, while for 25OHD
KW - 25-Hydroxyvitamin D
KW - Ionized calcium
KW - PTH
KW - Regression tree
UR - http://www.scopus.com/inward/record.url?scp=77955845738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955845738&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2010.06.013
DO - 10.1016/j.bone.2010.06.013
M3 - Article
C2 - 20601288
AN - SCOPUS:77955845738
VL - 47
SP - 626
EP - 630
JO - Bone
JF - Bone
SN - 8756-3282
IS - 3
ER -