Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status: A study in a large cohort of healthy subjects

Vincenzo Carnevale; Luciano Nieddu; Elisabetta Romagnoli; Claudia Battista; Maria Lucia Mascia; Iacopo Chiodini; Cristina Eller-Vainicher; Vincenzo Frusciante; Stefano Angelo Santini; Michele La Porta; Salvatore Minisola; Alfredo Scillitani

doi:10.1016/j.bone.2010.06.013

Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status: A study in a large cohort of healthy subjects

Vincenzo Carnevale, Luciano Nieddu, Elisabetta Romagnoli, Claudia Battista, Maria Lucia Mascia, Iacopo Chiodini, Cristina Eller-Vainicher, Vincenzo Frusciante, Stefano Angelo Santini, Michele La Porta, Salvatore Minisola, Alfredo Scillitani

Research output: Contribution to journal › Article

Abstract

Introduction: Previous papers investigating vitamin D status have often outlined the significant relationships between serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD), but the influence of ionized calcium levels has not been concomitantly considered. Design: Cross-sectional. Materials and methods: In 1050 healthy men (547) and women (503), serum ionized calcium (iCa), creatinine (Cr), albumin, 25OHD, and PTH were measured. After conventional analysis, a regression tree was fitted on the data set. Results: 25OHD and PTH values showed significant opposite seasonal changes. 25OHD levels negatively correlated with PTH, which in turn negatively correlated with iCa. A regression tree was fitted to the whole data set using PTH as the response variable and 25OHD and iCa as covariates. PTH concentration depended on that of iCa only in subjects with 25OHD levels>16.35. ng/mL, while for 25OHD

Original language	English
Pages (from-to)	626-630
Number of pages	5
Journal	Bone
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/j.bone.2010.06.013
Publication status	Published - Sep 2010

Keywords

25-Hydroxyvitamin D
Ionized calcium
PTH
Regression tree

ASJC Scopus subject areas

Physiology
Endocrinology, Diabetes and Metabolism
Histology

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Carnevale, V., Nieddu, L., Romagnoli, E., Battista, C., Mascia, M. L., Chiodini, I., Eller-Vainicher, C., Frusciante, V., Santini, S. A., La Porta, M., Minisola, S., & Scillitani, A. (2010). Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status: A study in a large cohort of healthy subjects. Bone, 47(3), 626-630. https://doi.org/10.1016/j.bone.2010.06.013

Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status : A study in a large cohort of healthy subjects. / Carnevale, Vincenzo; Nieddu, Luciano; Romagnoli, Elisabetta; Battista, Claudia; Mascia, Maria Lucia; Chiodini, Iacopo ; Eller-Vainicher, Cristina; Frusciante, Vincenzo; Santini, Stefano Angelo; La Porta, Michele; Minisola, Salvatore; Scillitani, Alfredo.

In: Bone, Vol. 47, No. 3, 09.2010, p. 626-630.

Research output: Contribution to journal › Article

Carnevale, V, Nieddu, L, Romagnoli, E, Battista, C, Mascia, ML, Chiodini, I , Eller-Vainicher, C, Frusciante, V, Santini, SA, La Porta, M, Minisola, S & Scillitani, A 2010, 'Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status: A study in a large cohort of healthy subjects', Bone, vol. 47, no. 3, pp. 626-630. https://doi.org/10.1016/j.bone.2010.06.013

Carnevale, Vincenzo ; Nieddu, Luciano ; Romagnoli, Elisabetta ; Battista, Claudia ; Mascia, Maria Lucia ; Chiodini, Iacopo ; Eller-Vainicher, Cristina ; Frusciante, Vincenzo ; Santini, Stefano Angelo ; La Porta, Michele ; Minisola, Salvatore ; Scillitani, Alfredo. / Regulation of PTH secretion by 25-hydroxyvitamin D and ionized calcium depends on vitamin D status : A study in a large cohort of healthy subjects. In: Bone. 2010 ; Vol. 47, No. 3. pp. 626-630.

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abstract = "Introduction: Previous papers investigating vitamin D status have often outlined the significant relationships between serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD), but the influence of ionized calcium levels has not been concomitantly considered. Design: Cross-sectional. Materials and methods: In 1050 healthy men (547) and women (503), serum ionized calcium (iCa), creatinine (Cr), albumin, 25OHD, and PTH were measured. After conventional analysis, a regression tree was fitted on the data set. Results: 25OHD and PTH values showed significant opposite seasonal changes. 25OHD levels negatively correlated with PTH, which in turn negatively correlated with iCa. A regression tree was fitted to the whole data set using PTH as the response variable and 25OHD and iCa as covariates. PTH concentration depended on that of iCa only in subjects with 25OHD levels>16.35. ng/mL, while for 25OHD",

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