TY - JOUR
T1 - Regulation of self-major histocompatibility complex reactive human T-cell clones
AU - Montani, M. S Gilardini
AU - Del Gallo, F.
AU - Gobbi, M.
AU - Lombardi, G.
AU - Piccolella, E.
AU - Pugliese, O.
AU - Colizzi, V.
PY - 1990
Y1 - 1990
N2 - The proliferative response of human T-lymphocyte clones, (TLC) specific for self-major histocompatibility complex (MHC) products either alone or associated with PPD epitopes are inhibited in vitro by dexamethasone (DEX) and by a non-specific inhibitory factor(s) (nsINH) produced by PPD-activated T-cells. The inhibiting effect has been investigated by preincubating autoreactive and PPD-specific TLC with nsINH or DEX. Results obtained indicate that T-lymphoxytes are the target of these two immunoregulatory molecules. Moreover, the addition of exogenous recombinant interleukin 2 (rIL-2) substantially reverses the inhibition observed in both nsINH- or DEX-treated cultures.
AB - The proliferative response of human T-lymphocyte clones, (TLC) specific for self-major histocompatibility complex (MHC) products either alone or associated with PPD epitopes are inhibited in vitro by dexamethasone (DEX) and by a non-specific inhibitory factor(s) (nsINH) produced by PPD-activated T-cells. The inhibiting effect has been investigated by preincubating autoreactive and PPD-specific TLC with nsINH or DEX. Results obtained indicate that T-lymphoxytes are the target of these two immunoregulatory molecules. Moreover, the addition of exogenous recombinant interleukin 2 (rIL-2) substantially reverses the inhibition observed in both nsINH- or DEX-treated cultures.
UR - http://www.scopus.com/inward/record.url?scp=0025344444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025344444&partnerID=8YFLogxK
U2 - 10.1016/0192-0561(90)90080-7
DO - 10.1016/0192-0561(90)90080-7
M3 - Article
C2 - 1691739
AN - SCOPUS:0025344444
VL - 12
SP - 255
EP - 260
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
SN - 0192-0561
IS - 3
ER -