Regulation of self-major histocompatibility complex reactive human T-cell clones

M. S Gilardini Montani, F. Del Gallo, M. Gobbi, G. Lombardi, E. Piccolella, O. Pugliese, V. Colizzi

Research output: Contribution to journalArticlepeer-review

Abstract

The proliferative response of human T-lymphocyte clones, (TLC) specific for self-major histocompatibility complex (MHC) products either alone or associated with PPD epitopes are inhibited in vitro by dexamethasone (DEX) and by a non-specific inhibitory factor(s) (nsINH) produced by PPD-activated T-cells. The inhibiting effect has been investigated by preincubating autoreactive and PPD-specific TLC with nsINH or DEX. Results obtained indicate that T-lymphoxytes are the target of these two immunoregulatory molecules. Moreover, the addition of exogenous recombinant interleukin 2 (rIL-2) substantially reverses the inhibition observed in both nsINH- or DEX-treated cultures.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalInternational Journal of Immunopharmacology
Volume12
Issue number3
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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