Regulation of stem cell differentiation by histone methyltransferases and demethylases

D. Pasini, A. P. Bracken, K. Agger, J. Christensen, K. Hansen, P. A C Cloos, K. Helin

Research output: Contribution to journalArticle

Abstract

The generation of different cell types from stem cells containing identical genetic information and their organization into tissues and organs during development is a highly complex process that requires defined transcriptional programs. Maintenance of such programs is epigenetically regulated and the factors involved in these processes are often essential for development. The activities required for cell-fate decisions are frequently deregulated in human tumors, and the elucidation of the molecular mechanisms that regulate these processes is therefore important for understanding both developmental processes and tumorigenesis.

Original languageEnglish
Pages (from-to)253-263
Number of pages11
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume73
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology

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