The generation of different cell types from stem cells containing identical genetic information and their organization into tissues and organs during development is a highly complex process that requires defined transcriptional programs. Maintenance of such programs is epigenetically regulated and the factors involved in these processes are often essential for development. The activities required for cell-fate decisions are frequently deregulated in human tumors, and the elucidation of the molecular mechanisms that regulate these processes is therefore important for understanding both developmental processes and tumorigenesis.
|Number of pages||11|
|Journal||Cold Spring Harbor Symposia on Quantitative Biology|
|Publication status||Published - 2008|
ASJC Scopus subject areas
- Molecular Biology