Regulation of the IL-12/IL-12R axis

A critical step in T-helper cell differentiation and effector function

Francesco Sinigaglia, Daniele D'Ambrosio, Paola Panina-Bordignon, Lars Rogge

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Interleukin (IL)-12 is required for the development of T-helper (Th) 1 cells, which have been shown to be important for protective cell-mediated immune responses against a variety of intracellular pathogens. Recent studies have clarified the sources and the regulation of IL-12 production leading to Th1 development against microbes. Expression of IL-12R is necessary for maintaining IL-12 responsiveness and controlling Th1 lineage commitment. Advances in this area have included a broader understanding of the factors involved in the regulation of the IL-12Rβ2 signaling component. Expression of this receptor subunit in humans is critically influenced by IL-12 and type I interferons. IL-12 signaling results in STAT4 activation and interferon (IFN)-γ production. Recent evidence suggests that IL-12 also modulates a number of genes involved in leukocyte trafficking. Thus, IL-12 is not only an important proinflammatory cytokine, which induces production of IFN-γ and subsequent activation of phagocytic cells but also plays a major role in regulating the migration and proper positioning of effector cells.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalImmunological Reviews
Volume170
DOIs
Publication statusPublished - 1999

Fingerprint

Interleukins
Interleukin-12
Cell Differentiation
Interferons
Interferon Type I
Th1 Cells
Phagocytes
Interleukin-1
Leukocytes
Cytokines
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Regulation of the IL-12/IL-12R axis : A critical step in T-helper cell differentiation and effector function. / Sinigaglia, Francesco; D'Ambrosio, Daniele; Panina-Bordignon, Paola; Rogge, Lars.

In: Immunological Reviews, Vol. 170, 1999, p. 65-72.

Research output: Contribution to journalArticle

Sinigaglia, Francesco ; D'Ambrosio, Daniele ; Panina-Bordignon, Paola ; Rogge, Lars. / Regulation of the IL-12/IL-12R axis : A critical step in T-helper cell differentiation and effector function. In: Immunological Reviews. 1999 ; Vol. 170. pp. 65-72.
@article{e56414efe1af4966926a0e83f98fd067,
title = "Regulation of the IL-12/IL-12R axis: A critical step in T-helper cell differentiation and effector function",
abstract = "Interleukin (IL)-12 is required for the development of T-helper (Th) 1 cells, which have been shown to be important for protective cell-mediated immune responses against a variety of intracellular pathogens. Recent studies have clarified the sources and the regulation of IL-12 production leading to Th1 development against microbes. Expression of IL-12R is necessary for maintaining IL-12 responsiveness and controlling Th1 lineage commitment. Advances in this area have included a broader understanding of the factors involved in the regulation of the IL-12Rβ2 signaling component. Expression of this receptor subunit in humans is critically influenced by IL-12 and type I interferons. IL-12 signaling results in STAT4 activation and interferon (IFN)-γ production. Recent evidence suggests that IL-12 also modulates a number of genes involved in leukocyte trafficking. Thus, IL-12 is not only an important proinflammatory cytokine, which induces production of IFN-γ and subsequent activation of phagocytic cells but also plays a major role in regulating the migration and proper positioning of effector cells.",
author = "Francesco Sinigaglia and Daniele D'Ambrosio and Paola Panina-Bordignon and Lars Rogge",
year = "1999",
doi = "10.1111/j.1600-065X.1999.tb01329.x",
language = "English",
volume = "170",
pages = "65--72",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Regulation of the IL-12/IL-12R axis

T2 - A critical step in T-helper cell differentiation and effector function

AU - Sinigaglia, Francesco

AU - D'Ambrosio, Daniele

AU - Panina-Bordignon, Paola

AU - Rogge, Lars

PY - 1999

Y1 - 1999

N2 - Interleukin (IL)-12 is required for the development of T-helper (Th) 1 cells, which have been shown to be important for protective cell-mediated immune responses against a variety of intracellular pathogens. Recent studies have clarified the sources and the regulation of IL-12 production leading to Th1 development against microbes. Expression of IL-12R is necessary for maintaining IL-12 responsiveness and controlling Th1 lineage commitment. Advances in this area have included a broader understanding of the factors involved in the regulation of the IL-12Rβ2 signaling component. Expression of this receptor subunit in humans is critically influenced by IL-12 and type I interferons. IL-12 signaling results in STAT4 activation and interferon (IFN)-γ production. Recent evidence suggests that IL-12 also modulates a number of genes involved in leukocyte trafficking. Thus, IL-12 is not only an important proinflammatory cytokine, which induces production of IFN-γ and subsequent activation of phagocytic cells but also plays a major role in regulating the migration and proper positioning of effector cells.

AB - Interleukin (IL)-12 is required for the development of T-helper (Th) 1 cells, which have been shown to be important for protective cell-mediated immune responses against a variety of intracellular pathogens. Recent studies have clarified the sources and the regulation of IL-12 production leading to Th1 development against microbes. Expression of IL-12R is necessary for maintaining IL-12 responsiveness and controlling Th1 lineage commitment. Advances in this area have included a broader understanding of the factors involved in the regulation of the IL-12Rβ2 signaling component. Expression of this receptor subunit in humans is critically influenced by IL-12 and type I interferons. IL-12 signaling results in STAT4 activation and interferon (IFN)-γ production. Recent evidence suggests that IL-12 also modulates a number of genes involved in leukocyte trafficking. Thus, IL-12 is not only an important proinflammatory cytokine, which induces production of IFN-γ and subsequent activation of phagocytic cells but also plays a major role in regulating the migration and proper positioning of effector cells.

UR - http://www.scopus.com/inward/record.url?scp=0032882699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032882699&partnerID=8YFLogxK

U2 - 10.1111/j.1600-065X.1999.tb01329.x

DO - 10.1111/j.1600-065X.1999.tb01329.x

M3 - Article

VL - 170

SP - 65

EP - 72

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

ER -