Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease

Giovanni D'Arena, Luca Laurenti, Maria Marta Minervini, Silvia Deaglio, Lisa Bonello, Laura De Martino, Laura De Padua, Lucia Savino, Michela Tarnani, Vincenzo De Feo, Nicola Cascavilla

Research output: Contribution to journalArticlepeer-review

Abstract

Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalLeukemia Research
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Autoimmunity
  • CD127
  • Chronic lymphocytic leukemia
  • Disregulation
  • Flow cytometry
  • Immune system
  • Regulatory T-cells

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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