Regulatory T cells for immunotherapy of autoimmune diseases: From the bench to the bedside

Sergio Rutella, Silvio Danese, Giuseppe Leone

Research output: Contribution to journalArticlepeer-review

Abstract

The induction of antigen-specific unresponsiveness or tolerance is critical for the prevention of autoimmunity and maintenance of immune homeostasis. The presence of regulatory T cells (Treg cells) has been recently demonstrated in animals and in humans. Interestingly, Treg cells may be either quantitatively or qualitatively altered in human autoimmune diseases, for example, multiple sclerosis, psoriasis, Type 1 diabetes and inflammatory bowel disease (IBD), suggesting a role in disease pathophysiology. The present review summarises the emerging literature on the developmental origin and function of human Treg cells. The potential clinical application of Treg cells to human autoimmune diseases and to post-transplantation graft-versus-host disease is discussed.

Original languageEnglish
Pages (from-to)1595-1616
Number of pages22
JournalExpert Opinion on Therapeutic Patents
Volume15
Issue number11
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Granulocyte colony-stimulating factor
  • IL-10
  • Regulatory T cell (Treg)
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Law

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