Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases

Giovanni D'Arena, Giovanni Rossi, Barbara Vannata, Silvia Deaglio, Giovanna Mansueto, Fiorella D'Auria, Teodora Statuto, Vittorio Simeon, Laura De Martino, Aurelio Marandino, Giovanni Del Poeta, Vincenzo De Feo, Pellegrino Musto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. Theyare thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predictive of the time to treatment, as well. Moreover, it is now clear that dysregulation in Tregs cell frequency and/or function may resultin a plethora of autoimmune diseases, including multiple sclerosis, type 1 diabetes mellitus, myasthenia gravis, systemic lupus erythematosus, autoimmune lymphoproliferative disorders, rheumatoid arthritis, and psoriasis. Efforts are made aiming to develop approachesto deplete Tregs or inhibit their function in cancer and autoimmune disorders, as well.

Original languageEnglish
Article numbere2012053
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume4
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Regulatory T-Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Autoimmune Diseases
Self Tolerance
Lymphoproliferative Disorders
Myasthenia Gravis
Type 1 Diabetes Mellitus
Psoriasis
Systemic Lupus Erythematosus
Multiple Sclerosis
Immunity
Rheumatoid Arthritis
Neoplasms
Homeostasis
Therapeutics

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

Cite this

Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases. / D'Arena, Giovanni; Rossi, Giovanni; Vannata, Barbara; Deaglio, Silvia; Mansueto, Giovanna; D'Auria, Fiorella; Statuto, Teodora; Simeon, Vittorio; De Martino, Laura; Marandino, Aurelio; Poeta, Giovanni Del; De Feo, Vincenzo; Musto, Pellegrino.

In: Mediterranean Journal of Hematology and Infectious Diseases, Vol. 4, No. 1, e2012053, 2012.

Research output: Contribution to journalArticle

D'Arena, G, Rossi, G, Vannata, B, Deaglio, S, Mansueto, G, D'Auria, F, Statuto, T, Simeon, V, De Martino, L, Marandino, A, Poeta, GD, De Feo, V & Musto, P 2012, 'Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases', Mediterranean Journal of Hematology and Infectious Diseases, vol. 4, no. 1, e2012053. https://doi.org/10.4084/MJHID.2012.053
D'Arena, Giovanni ; Rossi, Giovanni ; Vannata, Barbara ; Deaglio, Silvia ; Mansueto, Giovanna ; D'Auria, Fiorella ; Statuto, Teodora ; Simeon, Vittorio ; De Martino, Laura ; Marandino, Aurelio ; Poeta, Giovanni Del ; De Feo, Vincenzo ; Musto, Pellegrino. / Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases. In: Mediterranean Journal of Hematology and Infectious Diseases. 2012 ; Vol. 4, No. 1.
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