Regulatory T cells, leptin and angiogenesis

Valentina Pucino, Veronica De Rosa, Claudio Procaccini, Giuseppe Matarese

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Regulatory T cells (Treg cells) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance. Excess body weight and obesity are typified by 'low-degree' chronic inflammation and are associated with an increased risk of atherosclerosis, diabetes, fatty liver disease, autoimmune diseases and cancer. All these pathological conditions are characterized by chronic inflammation, abnormal cytokine production, elevated acute-phase reactants, and the activation of several inflammatory signaling pathways. In this context, the discovery of the adipose tissue-derived hormone leptin has shed fundamental insights on how these processes might occur. Leptin represents a link among metabolic disorders and immune tolerance; indeed, leptin can negatively affect the generation and proliferation of Treg cells, key players in this context. Treg cells play also a central role in tumor progression; different reports have proposed that tumor microenvironment can induce the recruitment of Treg cells which can promote tumor tolerance and angiogenesis through expression of suppressive molecules, cytokines and angiogenic factors (i.e. vascular endothelial growth factor, leptin). This work aims to discuss some of the most recent advances on the relationship between angiogenesis, leptin and immune tolerance, focusing on the role of Treg cell function in this context.

Original languageEnglish
Pages (from-to)155-169
Number of pages15
JournalChemical Immunology and Allergy
Volume99
DOIs
Publication statusPublished - 2014

Fingerprint

Regulatory T-Lymphocytes
Leptin
Immune Tolerance
Cytokines
Peripheral Tolerance
Inflammation
Neoplasms
Tumor Microenvironment
Acute-Phase Proteins
Angiogenesis Inducing Agents
Fatty Liver
Vascular Endothelial Growth Factor A
Autoimmune Diseases
Adipose Tissue
Liver Diseases
Atherosclerosis
Homeostasis
Obesity
Body Weight
Maintenance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Pucino, V., De Rosa, V., Procaccini, C., & Matarese, G. (2014). Regulatory T cells, leptin and angiogenesis. Chemical Immunology and Allergy, 99, 155-169. https://doi.org/10.1159/000353557

Regulatory T cells, leptin and angiogenesis. / Pucino, Valentina; De Rosa, Veronica; Procaccini, Claudio; Matarese, Giuseppe.

In: Chemical Immunology and Allergy, Vol. 99, 2014, p. 155-169.

Research output: Contribution to journalArticle

Pucino, V, De Rosa, V, Procaccini, C & Matarese, G 2014, 'Regulatory T cells, leptin and angiogenesis', Chemical Immunology and Allergy, vol. 99, pp. 155-169. https://doi.org/10.1159/000353557
Pucino, Valentina ; De Rosa, Veronica ; Procaccini, Claudio ; Matarese, Giuseppe. / Regulatory T cells, leptin and angiogenesis. In: Chemical Immunology and Allergy. 2014 ; Vol. 99. pp. 155-169.
@article{3f2699c857864658bda730e6181bfe70,
title = "Regulatory T cells, leptin and angiogenesis",
abstract = "Regulatory T cells (Treg cells) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance. Excess body weight and obesity are typified by 'low-degree' chronic inflammation and are associated with an increased risk of atherosclerosis, diabetes, fatty liver disease, autoimmune diseases and cancer. All these pathological conditions are characterized by chronic inflammation, abnormal cytokine production, elevated acute-phase reactants, and the activation of several inflammatory signaling pathways. In this context, the discovery of the adipose tissue-derived hormone leptin has shed fundamental insights on how these processes might occur. Leptin represents a link among metabolic disorders and immune tolerance; indeed, leptin can negatively affect the generation and proliferation of Treg cells, key players in this context. Treg cells play also a central role in tumor progression; different reports have proposed that tumor microenvironment can induce the recruitment of Treg cells which can promote tumor tolerance and angiogenesis through expression of suppressive molecules, cytokines and angiogenic factors (i.e. vascular endothelial growth factor, leptin). This work aims to discuss some of the most recent advances on the relationship between angiogenesis, leptin and immune tolerance, focusing on the role of Treg cell function in this context.",
author = "Valentina Pucino and {De Rosa}, Veronica and Claudio Procaccini and Giuseppe Matarese",
year = "2014",
doi = "10.1159/000353557",
language = "English",
volume = "99",
pages = "155--169",
journal = "Progress in Allergy",
issn = "1660-2242",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Regulatory T cells, leptin and angiogenesis

AU - Pucino, Valentina

AU - De Rosa, Veronica

AU - Procaccini, Claudio

AU - Matarese, Giuseppe

PY - 2014

Y1 - 2014

N2 - Regulatory T cells (Treg cells) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance. Excess body weight and obesity are typified by 'low-degree' chronic inflammation and are associated with an increased risk of atherosclerosis, diabetes, fatty liver disease, autoimmune diseases and cancer. All these pathological conditions are characterized by chronic inflammation, abnormal cytokine production, elevated acute-phase reactants, and the activation of several inflammatory signaling pathways. In this context, the discovery of the adipose tissue-derived hormone leptin has shed fundamental insights on how these processes might occur. Leptin represents a link among metabolic disorders and immune tolerance; indeed, leptin can negatively affect the generation and proliferation of Treg cells, key players in this context. Treg cells play also a central role in tumor progression; different reports have proposed that tumor microenvironment can induce the recruitment of Treg cells which can promote tumor tolerance and angiogenesis through expression of suppressive molecules, cytokines and angiogenic factors (i.e. vascular endothelial growth factor, leptin). This work aims to discuss some of the most recent advances on the relationship between angiogenesis, leptin and immune tolerance, focusing on the role of Treg cell function in this context.

AB - Regulatory T cells (Treg cells) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance. Excess body weight and obesity are typified by 'low-degree' chronic inflammation and are associated with an increased risk of atherosclerosis, diabetes, fatty liver disease, autoimmune diseases and cancer. All these pathological conditions are characterized by chronic inflammation, abnormal cytokine production, elevated acute-phase reactants, and the activation of several inflammatory signaling pathways. In this context, the discovery of the adipose tissue-derived hormone leptin has shed fundamental insights on how these processes might occur. Leptin represents a link among metabolic disorders and immune tolerance; indeed, leptin can negatively affect the generation and proliferation of Treg cells, key players in this context. Treg cells play also a central role in tumor progression; different reports have proposed that tumor microenvironment can induce the recruitment of Treg cells which can promote tumor tolerance and angiogenesis through expression of suppressive molecules, cytokines and angiogenic factors (i.e. vascular endothelial growth factor, leptin). This work aims to discuss some of the most recent advances on the relationship between angiogenesis, leptin and immune tolerance, focusing on the role of Treg cell function in this context.

UR - http://www.scopus.com/inward/record.url?scp=84900843530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900843530&partnerID=8YFLogxK

U2 - 10.1159/000353557

DO - 10.1159/000353557

M3 - Article

C2 - 24217608

AN - SCOPUS:84900843530

VL - 99

SP - 155

EP - 169

JO - Progress in Allergy

JF - Progress in Allergy

SN - 1660-2242

ER -