Regulatory T cells protect from autoimmune arthritis during pregnancy

Alba Munoz-Suano, Marinos Kallikourdis, Milka Sarris, Alexander G. Betz

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Pregnancy frequently has a beneficial effect on the autoimmune disease Rheumatoid Arthritis, ranging from improvement in clinical symptoms to complete remission. Despite decades of study, a mechanistic explanation remains elusive. Here, we demonstrate that an analogous pregnancy-induced remission can be observed in a mouse model of arthritis. We demonstrate that during pregnancy mice are protected from collagen-induced arthritis, but are still capable of launching normal immune responses to influenza infections. We examine the role of regulatory T (T R) cells in this beneficial effect. T R cells are essential for many aspects of immune tolerance, including the suppression of autoimmune responses. Remarkably, transfer of regulatory T cells from pregnant 'protected' mice was sufficient to confer protection to non-pregnant mice. These results suggest that regulatory T cells are responsible for the pregnancy-induced amelioration of arthritis.

Original languageEnglish
JournalJournal of Autoimmunity
Volume38
Issue number2-3
DOIs
Publication statusPublished - May 2012

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Regulatory T-Lymphocytes
Arthritis
Pregnancy
Immune Tolerance
Experimental Arthritis
Autoimmunity
Human Influenza
Autoimmune Diseases
Rheumatoid Arthritis
Infection

Keywords

  • Mouse model
  • Pregnancy
  • Regulatory T cells
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Regulatory T cells protect from autoimmune arthritis during pregnancy. / Munoz-Suano, Alba; Kallikourdis, Marinos; Sarris, Milka; Betz, Alexander G.

In: Journal of Autoimmunity, Vol. 38, No. 2-3, 05.2012.

Research output: Contribution to journalArticle

Munoz-Suano, Alba ; Kallikourdis, Marinos ; Sarris, Milka ; Betz, Alexander G. / Regulatory T cells protect from autoimmune arthritis during pregnancy. In: Journal of Autoimmunity. 2012 ; Vol. 38, No. 2-3.
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