Rehabilitation in Parkinson's disease: Assessing the outcome using objective metabolic measurements

Giuseppe Frazzitta, Roberto Maestri, Gabriella Bertotti, Davide Uccellini, Giacomo Bazzini, Paola Abelli, Roberto Aquilani

Research output: Contribution to journalArticle

Abstract

Objective measurements to assess the efficacy of rehabilitation treatment in Parkinson's disease, suitable to be carried out routinely in the clinical setting, are lacking. Metabolic parameters, reflecting the recruitment and co-ordination of muscle fibers, might be simple instrumental measurements suitable for use as outcome markers. Twenty parkinsonian patients underwent a 4-week rehabilitation treatment. Functional evaluation was based on Unified Parkinson's Disease Rating Scale Motor Section (UPDRS III), Berg's scale, 6-minute walking test (6MWT), and the metabolic data recorded during the 6MWT namely the active energy expenditure (AEE), the kinetics of the energy consumption curve, and the peak value of energy consumption. Both rating scales and gait improved significantly (UPDRS III decreased by 32%, Berg increased by 21% and the 6MWT increased by 17%). We observed significant improvements also in metabolic measurements (35, 18, and 15 improvement in the kinetics of the energy consumption, AEE, and peak value of energy consumption, respectively). Hence, the rehabilitation protocol improved functional characteristics of the patients and these improvements were clearly reflected also by the metabolic measurements. The improvement in clinical scores corresponded with an increase in energy consumption during the 6MWT, indicating greater speed in the recruitment of motor units and of a capacity to maintain this recruitment over time.

Original languageEnglish
Pages (from-to)609-614
Number of pages6
JournalMovement Disorders
Volume25
Issue number5
DOIs
Publication statusPublished - Apr 15 2010

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Walking
Parkinson Disease
Rehabilitation
Energy Metabolism
Neurophysiological Recruitment
Gait
Muscles
Therapeutics

Keywords

  • Outcome markers
  • Parkinson's disease
  • Rehabilitation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Frazzitta, G., Maestri, R., Bertotti, G., Uccellini, D., Bazzini, G., Abelli, P., & Aquilani, R. (2010). Rehabilitation in Parkinson's disease: Assessing the outcome using objective metabolic measurements. Movement Disorders, 25(5), 609-614. https://doi.org/10.1002/mds.22871

Rehabilitation in Parkinson's disease : Assessing the outcome using objective metabolic measurements. / Frazzitta, Giuseppe; Maestri, Roberto; Bertotti, Gabriella; Uccellini, Davide; Bazzini, Giacomo; Abelli, Paola; Aquilani, Roberto.

In: Movement Disorders, Vol. 25, No. 5, 15.04.2010, p. 609-614.

Research output: Contribution to journalArticle

Frazzitta, G, Maestri, R, Bertotti, G, Uccellini, D, Bazzini, G, Abelli, P & Aquilani, R 2010, 'Rehabilitation in Parkinson's disease: Assessing the outcome using objective metabolic measurements', Movement Disorders, vol. 25, no. 5, pp. 609-614. https://doi.org/10.1002/mds.22871
Frazzitta, Giuseppe ; Maestri, Roberto ; Bertotti, Gabriella ; Uccellini, Davide ; Bazzini, Giacomo ; Abelli, Paola ; Aquilani, Roberto. / Rehabilitation in Parkinson's disease : Assessing the outcome using objective metabolic measurements. In: Movement Disorders. 2010 ; Vol. 25, No. 5. pp. 609-614.
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