Rejection and tacrolimus conversion therapy in paediatric liver transplantation

M. Spada, V. Corno, M. Colledan, A. Segalin, A. Lucianetti, G. Torre, S. Riva, A. Sonzogni, W. Petz, B. Gridelli

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Rejection and efficacy of rescue therapy with tacrolimus were evaluated in 50 children who underwent primary, ABO-compatible, liver transplantation. Six patients who died within the first week and one child who underwent retransplantation from an ABO-incompatible donor were excluded from the study. No patient or graft were lost due to rejection. We observed 48 episodes of rejection in 33 patients. Fourteen patients required conversion to tacrolimus for steroid-resistant rejection with resolution of rejection. One of these children developed PTLD. Other indications for conversion were neurotoxicity and hirsutism. One patient developed blindness of unknown origin after the conversion. Other side effects of tacrolimus were minor and resolved by lowering the dose. Five patients developed rejection after conversion; all achieved resolution with either steroid therapy or increase of tacrolimus dose. In conclusion, our study confirms that tacrolimus is an effective rescue therapy for paediatric liver transplantation.

Original languageEnglish
JournalTransplant International
Volume13
Issue numberSUPPL. 1
Publication statusPublished - 2000

Fingerprint

Tacrolimus
Liver Transplantation
Pediatrics
Therapeutics
Steroids
Hirsutism
Blindness
Tissue Donors
Transplants

Keywords

  • Child
  • Human
  • Liver transplantation
  • Rejection
  • Tacrolimus

ASJC Scopus subject areas

  • Transplantation

Cite this

Spada, M., Corno, V., Colledan, M., Segalin, A., Lucianetti, A., Torre, G., ... Gridelli, B. (2000). Rejection and tacrolimus conversion therapy in paediatric liver transplantation. Transplant International, 13(SUPPL. 1).

Rejection and tacrolimus conversion therapy in paediatric liver transplantation. / Spada, M.; Corno, V.; Colledan, M.; Segalin, A.; Lucianetti, A.; Torre, G.; Riva, S.; Sonzogni, A.; Petz, W.; Gridelli, B.

In: Transplant International, Vol. 13, No. SUPPL. 1, 2000.

Research output: Contribution to journalArticle

Spada, M, Corno, V, Colledan, M, Segalin, A, Lucianetti, A, Torre, G, Riva, S, Sonzogni, A, Petz, W & Gridelli, B 2000, 'Rejection and tacrolimus conversion therapy in paediatric liver transplantation', Transplant International, vol. 13, no. SUPPL. 1.
Spada, M. ; Corno, V. ; Colledan, M. ; Segalin, A. ; Lucianetti, A. ; Torre, G. ; Riva, S. ; Sonzogni, A. ; Petz, W. ; Gridelli, B. / Rejection and tacrolimus conversion therapy in paediatric liver transplantation. In: Transplant International. 2000 ; Vol. 13, No. SUPPL. 1.
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