Relapse of breast cancer after adjuvant treatment in premenopausal and perimenopausal women: Patterns and prognoses

A. Goldhirsch, R. D. Gelber, M. Castiglione

Research output: Contribution to journalArticle

Abstract

Eight hundred eighteen premenopausal or perimenopausal breast cancer patients with axillary node metastases were treated with adjuvant chemotherapy (CMF) with or without endocrine treatment (prednisone, oophorectomy) in two concurrent prospective trials. Three hundred fifty-two (43%) had recurrent disease at a median follow-up time of 6 years. The 2-year survival percentages from time of first relapse were 16% for patients with initial metastases in visceral or multiple sites (including bone and soft tissue), 41% for those with regional metastases or skeletal relapse alone and 70% for patients with isolated local recurrence or contralateral breast cancer. The features that most influenced prognosis within the categories defined by site of first relapse were disease-free interval (

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalJournal of Clinical Oncology
Volume6
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Relapse of breast cancer after adjuvant treatment in premenopausal and perimenopausal women: Patterns and prognoses'. Together they form a unique fingerprint.

  • Cite this