Relation between chemotherapy dose, oestrogen receptor expression, and body-mass index

Marco Colleoni, Sigui Li, Richard D. Gelber, Karen N. Price, Alan S. Coates, Monica Castiglione-Gertsch, Aron Goldhirsch

Research output: Contribution to journalArticlepeer-review

Abstract

Clinicians often reduce chemotherapy doses when treating obese patients because of concerns about overdosing. We assessed dose-response according to body-mass index (BMI) and oestrogen receptor (ER) expression of the primary tumour in premenopausal patients with node-positive breast cancer treated with classical CMF (cyclophosphamide, methotrexate, and 5-fluorouracil). Obese patients were significantly more likely to receive a lower chemotherapy dose (

Original languageEnglish
Pages (from-to)1108-1110
Number of pages3
JournalLancet
Volume366
Issue number9491
DOIs
Publication statusPublished - Sep 24 2005

ASJC Scopus subject areas

  • Medicine(all)

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