Relation between circulating oxidized-LDL and metabolic syndrome in children with obesity: the role of hypertriglyceridemic waist phenotype

V. Calcaterra, R. De Giuseppe, G. Biino, M. Mantelli, S. Marchini, G. Bendotti, A. Made, M. A. Avanzini, C. Montalbano, G. Cossellu, D. Larizza, H. Cena

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Abstract

BACKGROUND: The association between oxidative stress (OS) and metabolic syndrome (MetS) has been reported in adults. We analyzed the relation between circulating oxidized low-density lipoproteins (Ox-LDL) and MetS in pediatric ages in order to define whether plasma Ox-LDL levels are correlated to obesity and whether oxidative damage, using serum Ox-LDL levels as a proxy, are associated with MetS. METHODS: We enrolled 178 children (11.8+/-2.6 years). On the basis of a body mass index (BMI) threshold, the subjects were classified as: normal weight BMI 97th percentile. Patients were classified as having MetS if they met three or more of the following criteria for age and sex: BMI >97th percentile, triglyceride levels >95th percentile, high-density lipoprotein (HDL) cholesterol level 95th percentile and impaired glucose tolerance. RESULTS: Obese children showed increased MetS prevalence (p=0.001) and higher Ox-LDL levels compared to normal- and overweight subjects (p
Original languageEnglish
Pages (from-to)1257-1263
Number of pages7
JournalJournal of pediatric endocrinology & metabolism : JPEM
Volume30
Issue number12
DOIs
Publication statusPublished - Nov 27 2017

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Keywords

  • children
  • metabolic syndrome (MetS)
  • obesity
  • oxidative damage
  • oxidized-low-density lipoproteins (Ox-LDL)

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