Relation between coronary atherosclerotic plaques and traditional risk factors in people with no history of cardiovascular disease undergoing multi-detector computed coronary angiography

Francesco F. Faletra, C. Klersy, I. D'Angeli, M. Penco, V. Procaccini, E. Pasotti, A. Marcolongo, G. B. Pedrazzini, S. De Castro, M. Scappaticci, T. Moccetti, A. Auricchio

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To prospectively investigate the prevalence of coronary artery plaques (CAP) as detected by computed tomography-based angiography in a large number of consecutive individuals with no history of coronary artery disease (CAD) or acute coronary syndrome; to evaluate whether traditional risk factors are related to prevalence of CAP and to the expected 10-year risk of first major or fatal cardiovascular event (CVE). Design: Prospective, single-centre, cross-sectional study. Setting: The division of Cardiology at Fondazione Cardiocentro Ticino Lugano, Switzerland. Methods: We prospectively included 920 consecutive individuals with no history of CAD who underwent computed tomography coronary angiography (CTCA). Risk estimation of fatal and non-fatal CVE was assessed using Global Assessment Risk (GAR) and Systematic Coronary Risk Evaluation (SCORE), respectively. Logistic regression was used to assess the association of risk factors with the prevalence of CAP. Results: CAP was found in 459 (49.9%) individuals. Older age, higher body mass index, male gender, diabetes, hypertension and dyslipidaemia all increased the likelihood of the CAP burden at univariable analysis (p

Original languageEnglish
Pages (from-to)1265-1272
Number of pages8
JournalHeart
Volume95
Issue number15
DOIs
Publication statusPublished - Aug 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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