Relation between food habits and p53 mutational spectrum in gastric cancer patients.

R. Fedriga, D. Calistri, O. Nanni, L. Cortesi, L. Saragoni, D. Amadori

Research output: Contribution to journalArticlepeer-review

Abstract

p53 tumour suppressor gene mutations were analysed in gastric cancer in relation to food habits and social class in 56 patients from a high risk region of Italy. Exons 5-8 were analysed with DGGE method on amplified DNA from formalin-fixed paraffin-embedded samples. All p53 mutations were observed in patients belonging to low social class and the majority of mutations were found in intestinal type cancers. A positive association was also found with low raw vegetables, fresh, dried and preserved fruits, and ascorbic acid intake. Moreover, specific types of mutations were significantly associated with particular factors, thus suggesting the presence of specific molecular etiologic process in stomach carcinogenesis.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalInternational Journal of Oncology
Volume17
Issue number1
Publication statusPublished - Jul 2000

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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