Relation between hemostatic variables and increase of common carotid intima-media thickness in patients with peripheral arterial disease

M. Cortellaro, D. Baldassarre, E. Cofrancesco, E. Tremoli, A. Colombo, C. Boschetti, R. Paoletti

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Increases in common carotid intima-media thickness (CC-1MT), as measured by B-mode ultrasonography, have been widely used in both population studies and clinical trials in the search for risk factors for early atherosclerosis progression and have been found to correlate with age and with high concentrations of low-density lipoprotein cholesterol, leukocytes, and hemoglobin. We have now investigated the relation between several baseline hemostatic and conventional risk factors and CC-IMT changes over 16 months in 64 patients with peripheral arterial disease randomly selected from the prospective PLAT study series. Methods: Samples from 24 patients (37.5%) who showed increases in CC-IMT during the follow-up period were compared with those from 40 (62.5%) in whom CC-IMT remained unchanged. Results: Baseline conventional risk actors and coagulation variables were similar in the two groups except for higher plasma concentrations of von Willebrand factor (vWF) (178.3±53.6% versus 141.2±53.7%, P=.01) and factor VII (FVII) (133.9±36.4% versus 107.0±27.3%, P=.001) in the patients with increased CC-IMT. CC-IMT increase correlated positively with plasma levels of FVII (r=.31, P

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalStroke
Volume27
Issue number3
Publication statusPublished - Mar 1996

Keywords

  • arteriosclerosis
  • carotid arteries
  • hemostatics
  • lipids
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

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